An integrated nanoplasmonic biosensor for monitoring cytokine secretion from single cells

Xiaokang Li, Maria Soler, Crispin Szydzik, Khashayar Khoshmanesh, Julien Schmidt, Filiz Yesilkoy, Alexander Belushkin, George Coukos, Arnan Mitchell, Hatice Altug

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearch

1 Citation (Scopus)


An innovative nanoplasmonic biosensor was presented for real-time label-free monitoring of cytokine secretion at single-cell resolution. This biosensor is integrated with a uniquely designed microfluidic device that provides a microchamber for cell incubation and fluid regulation for stable live cell monitoring. Different spatiotemporal profiles of interleukin-2 secretion were observed from single lymphoma cells. This novel configuration of label-free biosensor is promising for single-cell related studies.

Original languageEnglish
Title of host publication15th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME 2019)
Subtitle of host publicationConference Proceedings
EditorsPiero Malcovati, Nuno Lourenco, Fernando Garcia Redondo
Place of PublicationUnited States
PublisherIEEE, Institute of Electrical and Electronics Engineers
Number of pages4
ISBN (Electronic)9781728135496
ISBN (Print)9781728135502
Publication statusPublished - 1 Jul 2019
Externally publishedYes
EventConference on Ph.D. Research in Microelectronics and Electronics, PRIME 2019 - Lausanne, Switzerland
Duration: 15 Jul 201918 Jul 2019
Conference number: 15th


ConferenceConference on Ph.D. Research in Microelectronics and Electronics, PRIME 2019
Abbreviated titlePRINE 2019


  • label-free
  • microfluidics
  • nanoplasmonics
  • single-cell analysis

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