@inbook{fe29c94ab49749eeb954ee650db0631c,
title = "An In Vitro Model for Assessing Acute Lung Injury During Pancreatitis Development Using Primary Mouse Cell Co-cultures",
abstract = "Acute pancreatitis is a serious inflammatory disease of the pancreas that can lead to lung injury. Despite extensive research, the mechanisms underlying this complication are ill-defined. In recent years, in vitro co-culture systems have emerged as powerful tools for studying complex interactions between different cell types in disease. In the context of pancreatitis, pancreatic acinar epithelial cells produce and secrete digestive enzymes, and their cellular damage, death, and/or dysfunction is a major contributing factor to the onset of pancreatitis. Here, in this chapter we describe a co-culture system of acinar cells and lung epithelial progenitor/stem cells to model for lung injury associated with pancreatitis.",
keywords = "Acinar cells, Acute lung injury, In vitro co-cultures, Lung stem cell niche, Organoids, Pancreatitis",
author = "Saad, {Mohamed I.} and Jenkins, {Brendan J.}",
note = "Funding Information: B.J.J. is supported by a National Health and Medical Research Council of Australia (NHMRC) Senior Research Fellowship (APP1154279). This work was also financially supported in part through the Victorian State Government Operational Infrastructure Support Scheme. We would like to thank Associate Professor Rebecca Lim (Hudson Institute of Medical Research, Melbourne, Australia) and her team for their technical assistance in setting up 3D lung organoids. Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2023",
doi = "10.1007/978-1-0716-3331-1_6",
language = "English",
isbn = "9781071633304",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "71--80",
editor = "Jenkins, {Brendan J.}",
booktitle = "Inflammation and Cancer",
address = "United States of America",
edition = "2nd",
}