An in situ gastric pouch technique for direct measurement of the gastric absorption of drugs in the rat

Peter J. Worland; Olaf H. Drummer; Bevyn Jarrott

doi:10.1016/0160-5402(83)90033-5

An in situ gastric pouch technique for direct measurement of the gastric absorption of drugs in the rat

Peter J. Worland, Olaf H. Drummer, Bevyn Jarrott

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

The preparation of an in situ gastric pouch technique that will allow a direct measurement of drug absorption is described. This technique has been developed in rats, but could be easily utilized in different laboratory animals. This technique has the major advantages of providing a direct measurement of the quantity of drug crossing the gastric mucosa into the bloodstream and enabling a direct comparison with results obtained using in situ intestinal loop preparations.

Original language	English
Pages (from-to)	215-221
Number of pages	7
Journal	Journal of Pharmacological Methods
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/0160-5402(83)90033-5
Publication status	Published - Nov 1983
Externally published	Yes

Keywords

Drug absorption
In situ gastric pouch
Rat

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10.1016/0160-5402(83)90033-5

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title = "An in situ gastric pouch technique for direct measurement of the gastric absorption of drugs in the rat",

abstract = "The preparation of an in situ gastric pouch technique that will allow a direct measurement of drug absorption is described. This technique has been developed in rats, but could be easily utilized in different laboratory animals. This technique has the major advantages of providing a direct measurement of the quantity of drug crossing the gastric mucosa into the bloodstream and enabling a direct comparison with results obtained using in situ intestinal loop preparations.",

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author = "Worland, {Peter J.} and Drummer, {Olaf H.} and Bevyn Jarrott",

year = "1983",

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AU - Worland, Peter J.

AU - Drummer, Olaf H.

AU - Jarrott, Bevyn

PY - 1983/11

Y1 - 1983/11

N2 - The preparation of an in situ gastric pouch technique that will allow a direct measurement of drug absorption is described. This technique has been developed in rats, but could be easily utilized in different laboratory animals. This technique has the major advantages of providing a direct measurement of the quantity of drug crossing the gastric mucosa into the bloodstream and enabling a direct comparison with results obtained using in situ intestinal loop preparations.

AB - The preparation of an in situ gastric pouch technique that will allow a direct measurement of drug absorption is described. This technique has been developed in rats, but could be easily utilized in different laboratory animals. This technique has the major advantages of providing a direct measurement of the quantity of drug crossing the gastric mucosa into the bloodstream and enabling a direct comparison with results obtained using in situ intestinal loop preparations.

KW - Drug absorption

KW - In situ gastric pouch

KW - Rat

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JF - Journal of Pharmacological Methods

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ER -

An in situ gastric pouch technique for direct measurement of the gastric absorption of drugs in the rat

Abstract

Keywords

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