An Improved Process for the N-Demethylation of Opiate Alkaloids using an Iron(II) Catalyst in Acetate Buffer

Gaik Beng Orbell, Trent Damon Ashton, Peter John Scammells

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30 Citations (Scopus)


An improved process to N-demethylate opiate alkaloids utilising a solution of the ferrous porphyrin, tetrasodium 5,10,15,20-tetra(4-sulfophenyl)porphyrinatoiron(II) [=Fe(II)-TPPS (8)], in acetate buffer is described. This method provided the corresponding N-demethylated opiates in good yield with high reproducibility.
Original languageEnglish
Pages (from-to)283 - 286
Number of pages4
JournalAdvanced Synthesis and Catalysis
Issue number1-2
Publication statusPublished - 2009

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