An improved process to N-demethylate opiate alkaloids utilising a solution of the ferrous porphyrin, tetrasodium 5,10,15,20-tetra(4-sulfophenyl)porphyrinatoiron(II) [=Fe(II)-TPPS (8)], in acetate buffer is described. This method provided the corresponding N-demethylated opiates in good yield with high reproducibility.
|Pages (from-to)||283 - 286|
|Number of pages||4|
|Journal||Advanced Synthesis and Catalysis|
|Publication status||Published - 2009|