An immunosurveillance mechanism controls cancer cell ploidy

L Senovilla, Ilio Vitale, Isabelle Martins, Maximilien Tailler, Claire Pailleret, Mickael Michaud, Lorenzo Galluzzi, Sandy Adjemian, Oliver Kepp, Mireia Niso-Santano, Shenshi Shen, Guillermo Marino, Alfredo Criollo, Alice Boileve, Bastien Job, Sylvain Ladoire, Francois Ghiringhelli, Antonella Sistigu, Takahiro Yamazaki, Santiago Rello-VaronaClara Locher, Vichnou Poirier-Colame, Monique Talbot, Alexander Valent, Francesco Berardinelli, Antonio Antoccia, Fabiola Ciccosanti, Gian Maria Fimia, Mauro Piacentini, Antonio Fueyo, Nicole L Messina, Ming Li, Christopher J Chan, Verena Sigl, Guillaume Pourcher, Christoph Ruckenstuhl, Didac Carmona-Gutierrez, Vladimir Lazar, Josef M Penninger, Frank Madeo, Carlos Lopez-Otin, Mark J Smyth, Laurence Zitvogel, Maria Castedo, Guido Kroemer

Research output: Contribution to journalArticleResearchpeer-review

247 Citations (Scopus)

Abstract

We report the unexpected finding that the chromosomal content is also controlled indirectly, by an immunosurveillance mechanism that ensures the elimination of hyperploid cells.
Original languageEnglish
Pages (from-to)1678 - 1684
Number of pages7
JournalScience
Volume337
Issue number6102
DOIs
Publication statusPublished - 2012

Cite this

Senovilla, L., Vitale, I., Martins, I., Tailler, M., Pailleret, C., Michaud, M., Galluzzi, L., Adjemian, S., Kepp, O., Niso-Santano, M., Shen, S., Marino, G., Criollo, A., Boileve, A., Job, B., Ladoire, S., Ghiringhelli, F., Sistigu, A., Yamazaki, T., ... Kroemer, G. (2012). An immunosurveillance mechanism controls cancer cell ploidy. Science, 337(6102), 1678 - 1684. https://doi.org/10.1126/science.1224922