An immunosurveillance mechanism controls cancer cell ploidy

L Senovilla; Ilio Vitale; Isabelle Martins; Maximilien Tailler; Claire Pailleret; Mickael Michaud; Lorenzo Galluzzi; Sandy Adjemian; Oliver Kepp; Mireia Niso-Santano; Shenshi Shen; Guillermo Marino; Alfredo Criollo; Alice Boileve; Bastien Job; Sylvain Ladoire; Francois Ghiringhelli; Antonella Sistigu; Takahiro Yamazaki; Santiago Rello-Varona; Clara Locher; Vichnou Poirier-Colame; Monique Talbot; Alexander Valent; Francesco Berardinelli; Antonio Antoccia; Fabiola Ciccosanti; Gian Maria Fimia; Mauro Piacentini; Antonio Fueyo; Nicole L Messina; Ming Li; Christopher J Chan; Verena Sigl; Guillaume Pourcher; Christoph Ruckenstuhl; Didac Carmona-Gutierrez; Vladimir Lazar; Josef M Penninger; Frank Madeo; Carlos Lopez-Otin; Mark J Smyth; Laurence Zitvogel; Maria Castedo; Guido Kroemer

doi:10.1126/science.1224922

An immunosurveillance mechanism controls cancer cell ploidy

L Senovilla, Ilio Vitale, Isabelle Martins, Maximilien Tailler, Claire Pailleret, Mickael Michaud, Lorenzo Galluzzi, Sandy Adjemian, Oliver Kepp, Mireia Niso-Santano, Shenshi Shen, Guillermo Marino, Alfredo Criollo, Alice Boileve, Bastien Job, Sylvain Ladoire, Francois Ghiringhelli, Antonella Sistigu, Takahiro Yamazaki, Santiago Rello-VaronaClara Locher, Vichnou Poirier-Colame, Monique Talbot, Alexander Valent, Francesco Berardinelli, Antonio Antoccia, Fabiola Ciccosanti, Gian Maria Fimia, Mauro Piacentini, Antonio Fueyo, Nicole L Messina, Ming Li, Christopher J Chan, Verena Sigl, Guillaume Pourcher, Christoph Ruckenstuhl, Didac Carmona-Gutierrez, Vladimir Lazar, Josef M Penninger, Frank Madeo, Carlos Lopez-Otin, Mark J Smyth, Laurence Zitvogel, Maria Castedo, Guido Kroemer

Immunology Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

363 Citations (Scopus)

Abstract

We report the unexpected finding that the chromosomal content is also controlled indirectly, by an immunosurveillance mechanism that ensures the elimination of hyperploid cells.

Original language	English
Pages (from-to)	1678 - 1684
Number of pages	7
Journal	Science
Volume	337
Issue number	6102
DOIs	https://doi.org/10.1126/science.1224922
Publication status	Published - 2012

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10.1126/science.1224922

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Senovilla, L., Vitale, I., Martins, I., Tailler, M., Pailleret, C., Michaud, M., Galluzzi, L., Adjemian, S., Kepp, O., Niso-Santano, M., Shen, S., Marino, G., Criollo, A., Boileve, A., Job, B., Ladoire, S., Ghiringhelli, F., Sistigu, A., Yamazaki, T., ... Kroemer, G. (2012). An immunosurveillance mechanism controls cancer cell ploidy. Science, 337(6102), 1678 - 1684. https://doi.org/10.1126/science.1224922

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title = "An immunosurveillance mechanism controls cancer cell ploidy",

abstract = "We report the unexpected finding that the chromosomal content is also controlled indirectly, by an immunosurveillance mechanism that ensures the elimination of hyperploid cells.",

author = "L Senovilla and Ilio Vitale and Isabelle Martins and Maximilien Tailler and Claire Pailleret and Mickael Michaud and Lorenzo Galluzzi and Sandy Adjemian and Oliver Kepp and Mireia Niso-Santano and Shenshi Shen and Guillermo Marino and Alfredo Criollo and Alice Boileve and Bastien Job and Sylvain Ladoire and Francois Ghiringhelli and Antonella Sistigu and Takahiro Yamazaki and Santiago Rello-Varona and Clara Locher and Vichnou Poirier-Colame and Monique Talbot and Alexander Valent and Francesco Berardinelli and Antonio Antoccia and Fabiola Ciccosanti and Fimia, {Gian Maria} and Mauro Piacentini and Antonio Fueyo and Messina, {Nicole L} and Ming Li and Chan, {Christopher J} and Verena Sigl and Guillaume Pourcher and Christoph Ruckenstuhl and Didac Carmona-Gutierrez and Vladimir Lazar and Penninger, {Josef M} and Frank Madeo and Carlos Lopez-Otin and Smyth, {Mark J} and Laurence Zitvogel and Maria Castedo and Guido Kroemer",

year = "2012",

doi = "10.1126/science.1224922",

language = "English",

volume = "337",

pages = "1678 -- 1684",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science (AAAS)",

number = "6102",

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Senovilla, L, Vitale, I, Martins, I, Tailler, M, Pailleret, C, Michaud, M, Galluzzi, L, Adjemian, S, Kepp, O, Niso-Santano, M, Shen, S, Marino, G, Criollo, A, Boileve, A, Job, B, Ladoire, S, Ghiringhelli, F, Sistigu, A, Yamazaki, T, Rello-Varona, S, Locher, C, Poirier-Colame, V, Talbot, M, Valent, A, Berardinelli, F, Antoccia, A, Ciccosanti, F, Fimia, GM, Piacentini, M, Fueyo, A, Messina, NL, Li, M, Chan, CJ, Sigl, V, Pourcher, G, Ruckenstuhl, C, Carmona-Gutierrez, D, Lazar, V, Penninger, JM, Madeo, F, Lopez-Otin, C, Smyth, MJ, Zitvogel, L, Castedo, M & Kroemer, G 2012, 'An immunosurveillance mechanism controls cancer cell ploidy', Science, vol. 337, no. 6102, pp. 1678 - 1684. https://doi.org/10.1126/science.1224922

TY - JOUR

T1 - An immunosurveillance mechanism controls cancer cell ploidy

AU - Senovilla, L

AU - Vitale, Ilio

AU - Martins, Isabelle

AU - Tailler, Maximilien

AU - Pailleret, Claire

AU - Michaud, Mickael

AU - Galluzzi, Lorenzo

AU - Adjemian, Sandy

AU - Kepp, Oliver

AU - Niso-Santano, Mireia

AU - Shen, Shenshi

AU - Marino, Guillermo

AU - Criollo, Alfredo

AU - Boileve, Alice

AU - Job, Bastien

AU - Ladoire, Sylvain

AU - Ghiringhelli, Francois

AU - Sistigu, Antonella

AU - Yamazaki, Takahiro

AU - Rello-Varona, Santiago

AU - Locher, Clara

AU - Poirier-Colame, Vichnou

AU - Talbot, Monique

AU - Valent, Alexander

AU - Berardinelli, Francesco

AU - Antoccia, Antonio

AU - Ciccosanti, Fabiola

AU - Fimia, Gian Maria

AU - Piacentini, Mauro

AU - Fueyo, Antonio

AU - Messina, Nicole L

AU - Li, Ming

AU - Chan, Christopher J

AU - Sigl, Verena

AU - Pourcher, Guillaume

AU - Ruckenstuhl, Christoph

AU - Carmona-Gutierrez, Didac

AU - Lazar, Vladimir

AU - Penninger, Josef M

AU - Madeo, Frank

AU - Lopez-Otin, Carlos

AU - Smyth, Mark J

AU - Zitvogel, Laurence

AU - Castedo, Maria

AU - Kroemer, Guido

PY - 2012

Y1 - 2012

N2 - We report the unexpected finding that the chromosomal content is also controlled indirectly, by an immunosurveillance mechanism that ensures the elimination of hyperploid cells.

AB - We report the unexpected finding that the chromosomal content is also controlled indirectly, by an immunosurveillance mechanism that ensures the elimination of hyperploid cells.

UR - http://www.sciencemag.org/content/337/6102/1678.full.pdf

U2 - 10.1126/science.1224922

DO - 10.1126/science.1224922

M3 - Article

SN - 0036-8075

VL - 337

SP - 1678

EP - 1684

JO - Science

JF - Science

IS - 6102

ER -

An immunosurveillance mechanism controls cancer cell ploidy

Abstract

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