An HLA-A2-restricted T-Cell epitope mapped to the BNLF2a immune evasion protein of epstein-barr virus that inhibits TAP

Melissa J Bell, Rachel J.M. Abbott, Nathan P. Croft, Andrew D Hislop, Scott R Burrows

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9 Citations (Scopus)

Abstract

The early lytic cycle protein of Epstein-Barr virus (EBV), BNLF2a, has recently been shown to play a critical role in immune evasion by inhibiting the peptide transporter associated with antigen processing (TAP), thereby blocking antigen-specific CD8+ T-cell recognition of many lytic cycle antigens. Surprisingly, we now show that a peptide (50VLFGLLCLL 58) from the hydrophobic C-terminal region of this small (60-amino-acid) EBV protein is efficiently presented by the common class I allele HLA-A2 for recognition by cytotoxic T lymphocytes. The mechanism for this unexpected finding was revealed by experiments showing that this epitope is processed and presented independently of TAP.

Original languageEnglish
Pages (from-to)2783-2788
Number of pages6
JournalJournal of Virology
Volume83
Issue number6
DOIs
Publication statusPublished - Mar 2009
Externally publishedYes

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