An exploratory analysis of go/nogo event-related potentials in major depression and depression following traumatic brain injury

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are estimated to be between 20% and 45%, a higher prevalence than that seen in the general population. These increased rates may be due to specific changes in brain function following TBI. Event related potentials (ERPs) are well suited for measuring the electrophysiological differences between groups in areas of cognitive processing impaired in both MDD and TBI, such as response inhibition. The current study presented an emotional Go/Nogo task (with schematic emotional faces as stimuli) to participants with TBI, participants with MDD, and participants with both TBI and MDD (TBI-MDD). Topographical distribution of activity and global field power comparisons were made across stimulus-locked epochs between these groups and healthy controls. The results indicated that ERPs were not altered by TBI alone. Both MDD and TBI-MDD groups showed similar alterations in topographical distribution and global field power in the N2 window, as well as late epoch alterations. The MDD and TBI-MDD groups showed significantly less fronto-central negativity during the N2 window in Nogo trials compared with the control group. The MDD and TBI-MDD groups also showed significantly less global field power in Nogo trials than Go trials during the N2 window while the control group showed the opposite pattern. The MDD and TBI-MDD groups showed no mood-congruent bias in behavioural or ERP measures. The results suggest that TBI-MDD displays similar electrophysiological changes to those found in the MDD group without TBI.
Original languageEnglish
Pages (from-to)324-334
Number of pages11
JournalPsychiatry Research - Neuroimaging
Volume224
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Response inhibition
  • Event-related potentials
  • Nogo-N2
  • Major depressive disorder
  • Traumatic brain injury

Cite this

@article{32ab87b1fb024ad197bfb439cd6070cc,
title = "An exploratory analysis of go/nogo event-related potentials in major depression and depression following traumatic brain injury",
abstract = "Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are estimated to be between 20{\%} and 45{\%}, a higher prevalence than that seen in the general population. These increased rates may be due to specific changes in brain function following TBI. Event related potentials (ERPs) are well suited for measuring the electrophysiological differences between groups in areas of cognitive processing impaired in both MDD and TBI, such as response inhibition. The current study presented an emotional Go/Nogo task (with schematic emotional faces as stimuli) to participants with TBI, participants with MDD, and participants with both TBI and MDD (TBI-MDD). Topographical distribution of activity and global field power comparisons were made across stimulus-locked epochs between these groups and healthy controls. The results indicated that ERPs were not altered by TBI alone. Both MDD and TBI-MDD groups showed similar alterations in topographical distribution and global field power in the N2 window, as well as late epoch alterations. The MDD and TBI-MDD groups showed significantly less fronto-central negativity during the N2 window in Nogo trials compared with the control group. The MDD and TBI-MDD groups also showed significantly less global field power in Nogo trials than Go trials during the N2 window while the control group showed the opposite pattern. The MDD and TBI-MDD groups showed no mood-congruent bias in behavioural or ERP measures. The results suggest that TBI-MDD displays similar electrophysiological changes to those found in the MDD group without TBI.",
keywords = "Response inhibition, Event-related potentials, Nogo-N2, Major depressive disorder, Traumatic brain injury",
author = "Neil Bailey and Hoy, {Kate Elizabeth} and Maller, {Jerome Joseph} and Rebecca Segrave and Thomson, {Richard Hilton Siddall} and Nicholas Williams and Daskalakis, {Zafiris Jeff} and Fitzgerald, {Paul Bernard}",
year = "2014",
doi = "10.1016/j.pscychresns.2014.09.008",
language = "English",
volume = "224",
pages = "324--334",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - An exploratory analysis of go/nogo event-related potentials in major depression and depression following traumatic brain injury

AU - Bailey, Neil

AU - Hoy, Kate Elizabeth

AU - Maller, Jerome Joseph

AU - Segrave, Rebecca

AU - Thomson, Richard Hilton Siddall

AU - Williams, Nicholas

AU - Daskalakis, Zafiris Jeff

AU - Fitzgerald, Paul Bernard

PY - 2014

Y1 - 2014

N2 - Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are estimated to be between 20% and 45%, a higher prevalence than that seen in the general population. These increased rates may be due to specific changes in brain function following TBI. Event related potentials (ERPs) are well suited for measuring the electrophysiological differences between groups in areas of cognitive processing impaired in both MDD and TBI, such as response inhibition. The current study presented an emotional Go/Nogo task (with schematic emotional faces as stimuli) to participants with TBI, participants with MDD, and participants with both TBI and MDD (TBI-MDD). Topographical distribution of activity and global field power comparisons were made across stimulus-locked epochs between these groups and healthy controls. The results indicated that ERPs were not altered by TBI alone. Both MDD and TBI-MDD groups showed similar alterations in topographical distribution and global field power in the N2 window, as well as late epoch alterations. The MDD and TBI-MDD groups showed significantly less fronto-central negativity during the N2 window in Nogo trials compared with the control group. The MDD and TBI-MDD groups also showed significantly less global field power in Nogo trials than Go trials during the N2 window while the control group showed the opposite pattern. The MDD and TBI-MDD groups showed no mood-congruent bias in behavioural or ERP measures. The results suggest that TBI-MDD displays similar electrophysiological changes to those found in the MDD group without TBI.

AB - Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are estimated to be between 20% and 45%, a higher prevalence than that seen in the general population. These increased rates may be due to specific changes in brain function following TBI. Event related potentials (ERPs) are well suited for measuring the electrophysiological differences between groups in areas of cognitive processing impaired in both MDD and TBI, such as response inhibition. The current study presented an emotional Go/Nogo task (with schematic emotional faces as stimuli) to participants with TBI, participants with MDD, and participants with both TBI and MDD (TBI-MDD). Topographical distribution of activity and global field power comparisons were made across stimulus-locked epochs between these groups and healthy controls. The results indicated that ERPs were not altered by TBI alone. Both MDD and TBI-MDD groups showed similar alterations in topographical distribution and global field power in the N2 window, as well as late epoch alterations. The MDD and TBI-MDD groups showed significantly less fronto-central negativity during the N2 window in Nogo trials compared with the control group. The MDD and TBI-MDD groups also showed significantly less global field power in Nogo trials than Go trials during the N2 window while the control group showed the opposite pattern. The MDD and TBI-MDD groups showed no mood-congruent bias in behavioural or ERP measures. The results suggest that TBI-MDD displays similar electrophysiological changes to those found in the MDD group without TBI.

KW - Response inhibition

KW - Event-related potentials

KW - Nogo-N2

KW - Major depressive disorder

KW - Traumatic brain injury

U2 - 10.1016/j.pscychresns.2014.09.008

DO - 10.1016/j.pscychresns.2014.09.008

M3 - Article

VL - 224

SP - 324

EP - 334

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 3

ER -