An essential role in liver development for transcription factor XBP-1

Andreas M. Reimold, Amit Etkin, Isabelle Clauss, Andrew Perkins, Daniel S. Friend, John Zhang, Heidi F. Horton, Andrew Scott, Stuart H. Orkin, Michael C. Byrne, Michael J. Grusby, Laurie H. Glimcher

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420 Citations (Scopus)

Abstract

XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP- 1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalGenes & Development
Volume14
Issue number2
Publication statusPublished - 15 Jan 2000
Externally publishedYes

Keywords

  • Acute phase protein
  • Apoptosis
  • CREB/ATF family
  • Hepatocyte
  • Liver development
  • Transcription factors

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