An essential role in liver development for transcription factor XBP-1

Andreas M. Reimold; Amit Etkin; Isabelle Clauss; Andrew Perkins; Daniel S. Friend; John Zhang; Heidi F. Horton; Andrew Scott; Stuart H. Orkin; Michael C. Byrne; Michael J. Grusby; Laurie H. Glimcher

An essential role in liver development for transcription factor XBP-1

Andreas M. Reimold, Amit Etkin, Isabelle Clauss, Andrew Perkins, Daniel S. Friend, John Zhang, Heidi F. Horton, Andrew Scott, Stuart H. Orkin, Michael C. Byrne, Michael J. Grusby, Laurie H. Glimcher

Research output: Contribution to journal › Article › Research › peer-review

467 Citations (Scopus)

Abstract

XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP- 1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.

Original language	English
Pages (from-to)	152-157
Number of pages	6
Journal	Genes & Development
Volume	14
Issue number	2
Publication status	Published - 15 Jan 2000
Externally published	Yes

Keywords

Acute phase protein
Apoptosis
CREB/ATF family
Hepatocyte
Liver development
Transcription factors

Cite this

@article{81963c49a828402fbf69684cbf602134,

title = "An essential role in liver development for transcription factor XBP-1",

abstract = "XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP- 1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.",

keywords = "Acute phase protein, Apoptosis, CREB/ATF family, Hepatocyte, Liver development, Transcription factors",

author = "Reimold, {Andreas M.} and Amit Etkin and Isabelle Clauss and Andrew Perkins and Friend, {Daniel S.} and John Zhang and Horton, {Heidi F.} and Andrew Scott and Orkin, {Stuart H.} and Byrne, {Michael C.} and Grusby, {Michael J.} and Glimcher, {Laurie H.}",

year = "2000",

month = jan,

day = "15",

language = "English",

volume = "14",

pages = "152--157",

journal = "Genes & Development",

issn = "0890-9369",

publisher = "Cold Spring Harbor Laboratory Press",

number = "2",

}

TY - JOUR

T1 - An essential role in liver development for transcription factor XBP-1

AU - Reimold, Andreas M.

AU - Etkin, Amit

AU - Clauss, Isabelle

AU - Perkins, Andrew

AU - Friend, Daniel S.

AU - Zhang, John

AU - Horton, Heidi F.

AU - Scott, Andrew

AU - Orkin, Stuart H.

AU - Byrne, Michael C.

AU - Grusby, Michael J.

AU - Glimcher, Laurie H.

PY - 2000/1/15

Y1 - 2000/1/15

N2 - XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP- 1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.

AB - XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP- 1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.

KW - Acute phase protein

KW - Apoptosis

KW - CREB/ATF family

KW - Hepatocyte

KW - Liver development

KW - Transcription factors

UR - http://www.scopus.com/inward/record.url?scp=0034650851&partnerID=8YFLogxK

M3 - Article

C2 - 10652269

AN - SCOPUS:0034650851

SN - 0890-9369

VL - 14

SP - 152

EP - 157

JO - Genes & Development

JF - Genes & Development

IS - 2

ER -

An essential role in liver development for transcription factor XBP-1

Abstract

Keywords

Other files and links

Cite this