An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state

Mikael E Pedersen, Goda Snieckute, Konstantinos Kagias, Camilla Nehammer, Hinke A B Multhaupt, John R Couchman, Roger D J Pocock

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Abstract

An appropriate balance in glycosylation of proteoglycans is crucial for their ability to regulate animal development. Here, we report that the Caenorhabditis elegans microRNA mir-79, an ortholog of mammalian miR-9, controls sugar-chain homeostasis by targeting two proteins in the proteoglycan biosynthetic pathway: a chondroitin synthase (SQV-5; squashed vulva-5) and a uridine 5 -diphosphate-sugar transporter (SQV-7). Loss of mir-79 causes neurodevelopmental defects through SQV-5 and SQV-7 dysregulation in the epidermis. This results in a partial shutdown of heparan sulfate biosynthesis that impinges on a LON-2/glypican pathway and disrupts neuronal migration. Our results identify a regulatory axis controlled by a conserved microRNA that maintains proteoglycan homeostasis in cells.
Original languageEnglish
Pages (from-to)1404 - 1408
Number of pages5
JournalScience
Volume341
Issue number6152
DOIs
Publication statusPublished - 2013
Externally publishedYes

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