An efficient method for the synthesis of enantiopure 2,3-anti-propionate aldols involving a 3,5-syn- or anti-diol subunit through chiral borane-mediated enantioselective aldol reaction coupled with radical reduction

Syun-ichi Kiyooka, Shahid Abdus Kazi

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14 Citations (Scopus)


2,3-Anti-propionate aldols involving a 3,5-syn- or anti-diol subunit, versatile enantiopure segments available for macrolide synthesis, were prepd. by a chiral oxazaborolidinone-promoted asym. aldol reaction with BrMeC:C(OEt)OSiMe3 and subsequent highly anti-preferential radical debromination. [on SciFinder(R)]
Original languageEnglish
Pages (from-to)2633 - 2637
Number of pages5
JournalTetrahedron Letters
Issue number15
Publication statusPublished - 2000
Externally publishedYes

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