An atlas of serpin conformations

James Whisstock, Richard Skinner, Arthur M. Lesk

Research output: Contribution to journalReview ArticleResearchpeer-review

162 Citations (Scopus)


The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed→relaxed (S→R) transition. This article is a guide to the known serpin conformations and their biological significance.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalTrends in Biochemical Sciences
Issue number2
Publication statusPublished - Feb 1998
Externally publishedYes

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