Projects per year
Vaccine success relies on the formation of immunity. Humoral immunity is critical and is mediated by long-lived antibody-secreting cells and memory B cells (MBCs). Chronic infectious diseases cause a significant global burden of disease; pathogens that evade the immune system can cause phenotypical and functional changes to immune memory populations. Thus, recent studies have focused on MBC subset function. IgM+ MBCs have emerged as important early responders in malaria. Atypical MBCs have functional qualities associated with exhaustion in chronic infectious diseases, but the requirements for their formation and where they localize remains unknown. Similarly, the T-bet-driven transcriptional program drives formation of MBCs phenotypically similar to atypical MBCs. Identifying protective or detrimental roles of MBC subsets, and their regulators, will be important for clinical intervention.
|Number of pages||8|
|Journal||Current Opinion in Immunology|
|Publication status||Published - 1 Apr 2017|
- 1 Finished
How the immune system responds to different types of infection and establishes immunity
Jacobson, K. & Groom, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/14 → 31/01/18