An animal model of chronic placental insufficiency: Relevance to neurodevelopmental disorders including schizophrenia

Alexandra H Rehn; Maarten van den Buuse; David Leon Copolov; Todd Briscoe; Gavin W Lambert; Sandra M Rees

An animal model of chronic placental insufficiency: Relevance to neurodevelopmental disorders including schizophrenia

Alexandra H Rehn, Maarten van den Buuse, David Leon Copolov, Todd Briscoe, Gavin W Lambert, Sandra M Rees

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Evidence now suggests that compromised prenatal brain development may increase the risk for the manifestation of neurological disorders such as schizophrenia. We present a guinea-pig model which mimics a condition of human pregnancy, namely, chronic placental insufficiency. Previously we reported that at term there are changes in the brains of these offspring which are relevant to changes in patients with schizophrenia. The aim of this study was to examine whether deficits in brain structure persist to adolescence and young adulthood (8-12 weeks) and have implications for behavioral function

Original language	English
Pages (from-to)	381 - 391
Number of pages	11
Journal	Neuroscience
Volume	129
Issue number	2
Publication status	Published - 2004

Cite this

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title = "An animal model of chronic placental insufficiency: Relevance to neurodevelopmental disorders including schizophrenia",

abstract = "Evidence now suggests that compromised prenatal brain development may increase the risk for the manifestation of neurological disorders such as schizophrenia. We present a guinea-pig model which mimics a condition of human pregnancy, namely, chronic placental insufficiency. Previously we reported that at term there are changes in the brains of these offspring which are relevant to changes in patients with schizophrenia. The aim of this study was to examine whether deficits in brain structure persist to adolescence and young adulthood (8-12 weeks) and have implications for behavioral function",

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T1 - An animal model of chronic placental insufficiency: Relevance to neurodevelopmental disorders including schizophrenia

AU - Rehn, Alexandra H

AU - van den Buuse, Maarten

AU - Copolov, David Leon

AU - Briscoe, Todd

AU - Lambert, Gavin W

AU - Rees, Sandra M

PY - 2004

Y1 - 2004

N2 - Evidence now suggests that compromised prenatal brain development may increase the risk for the manifestation of neurological disorders such as schizophrenia. We present a guinea-pig model which mimics a condition of human pregnancy, namely, chronic placental insufficiency. Previously we reported that at term there are changes in the brains of these offspring which are relevant to changes in patients with schizophrenia. The aim of this study was to examine whether deficits in brain structure persist to adolescence and young adulthood (8-12 weeks) and have implications for behavioral function

AB - Evidence now suggests that compromised prenatal brain development may increase the risk for the manifestation of neurological disorders such as schizophrenia. We present a guinea-pig model which mimics a condition of human pregnancy, namely, chronic placental insufficiency. Previously we reported that at term there are changes in the brains of these offspring which are relevant to changes in patients with schizophrenia. The aim of this study was to examine whether deficits in brain structure persist to adolescence and young adulthood (8-12 weeks) and have implications for behavioral function

UR - http://www.ncbi.nlm.nih.gov/pubmed/15501595

M3 - Article

SN - 0306-4522

VL - 129

SP - 381

EP - 391

JO - Neuroscience

JF - Neuroscience

IS - 2

ER -

An animal model of chronic placental insufficiency: Relevance to neurodevelopmental disorders including schizophrenia

Abstract

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