An animal model of chronic placental insufficiency: Relevance to neurodevelopmental disorders including schizophrenia

Alexandra H Rehn, Maarten van den Buuse, David Leon Copolov, Todd Briscoe, Gavin W Lambert, Sandra M Rees

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63 Citations (Scopus)

Abstract

Evidence now suggests that compromised prenatal brain development may increase the risk for the manifestation of neurological disorders such as schizophrenia. We present a guinea-pig model which mimics a condition of human pregnancy, namely, chronic placental insufficiency. Previously we reported that at term there are changes in the brains of these offspring which are relevant to changes in patients with schizophrenia. The aim of this study was to examine whether deficits in brain structure persist to adolescence and young adulthood (8-12 weeks) and have implications for behavioral function
Original languageEnglish
Pages (from-to)381 - 391
Number of pages11
JournalNeuroscience
Volume129
Issue number2
Publication statusPublished - 2004

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