An alternate synthesis of enantiomerically pure levetiracetam (Keppra®)

M. Mujahid; P. Mujumdar; M. Sasikumar; S. S. Kunte; M. Muthukrishnan

doi:10.1016/j.tetasy.2012.10.006

An alternate synthesis of enantiomerically pure levetiracetam (Keppra®)

M. Mujahid, P. Mujumdar, M. Sasikumar, S. S. Kunte, M. Muthukrishnan

Research output: Contribution to journal › Article › Research › peer-review

18 Citations (Scopus)

Abstract

A simple and efficient synthesis of levetiracetam has been achieved with high enantiopurity (>99%) starting from commercially available benzyl glycidyl ether. The method is amenable for industrial scale-up.

Original language	English
Pages (from-to)	1512-1515
Number of pages	4
Journal	Tetrahedron Asymmetry
Volume	23
Issue number	20-21
DOIs	https://doi.org/10.1016/j.tetasy.2012.10.006
Publication status	Published - 15 Nov 2012
Externally published	Yes

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10.1016/j.tetasy.2012.10.006

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title = "An alternate synthesis of enantiomerically pure levetiracetam (Keppra{\textregistered})",

abstract = "A simple and efficient synthesis of levetiracetam has been achieved with high enantiopurity (>99\%) starting from commercially available benzyl glycidyl ether. The method is amenable for industrial scale-up.",

author = "M. Mujahid and P. Mujumdar and M. Sasikumar and Kunte, \{S. S.\} and M. Muthukrishnan",

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AU - Mujahid, M.

AU - Mujumdar, P.

AU - Sasikumar, M.

AU - Kunte, S. S.

AU - Muthukrishnan, M.

PY - 2012/11/15

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N2 - A simple and efficient synthesis of levetiracetam has been achieved with high enantiopurity (>99%) starting from commercially available benzyl glycidyl ether. The method is amenable for industrial scale-up.

AB - A simple and efficient synthesis of levetiracetam has been achieved with high enantiopurity (>99%) starting from commercially available benzyl glycidyl ether. The method is amenable for industrial scale-up.

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U2 - 10.1016/j.tetasy.2012.10.006

DO - 10.1016/j.tetasy.2012.10.006

M3 - Article

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SN - 0957-4166

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JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 20-21

ER -

An alternate synthesis of enantiomerically pure levetiracetam (Keppra®)

Abstract

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