Amyloidosis: A rheumatological perspective on diagnosis, further investigation and treatment

Simon K.L. Lam, G. S. Ngian, R. Travers, K. K.T. Lim

Research output: Contribution to journalArticleOtherpeer-review


In this Grand Round, we present a 58-year-old man with a presumptive diagnosis of rheumatoid arthritis (RA) who was being managed by a plastic surgery unit for a dorsal swelling of his right hand. While awaiting surgery for this lesion, he sustained a pathological fracture of his left neck of femur. This necessitated a total hip joint replacement and pathology revealed amyloidosis. Excision of the hand swelling also revealed amyloidosis as the cause. We discuss the ways in which amyloidosis can mimic musculoskeletal disease as well as the importance and some potential pitfalls of further investigation and management once the diagnosis of amyloidosis has been made.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalInternational Journal of Rheumatic Diseases
Issue number1
Publication statusPublished - 1 Apr 2008
Externally publishedYes


  • Amyloidosis
  • Inflammatory arthritis
  • Pathological fracture
  • Review

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