Amyloidosis: A rheumatological perspective on diagnosis, further investigation and treatment

Simon K.L. Lam; G. S. Ngian; R. Travers; K. K.T. Lim

doi:10.1111/j.1756-185X.2008.00331.x

Amyloidosis: A rheumatological perspective on diagnosis, further investigation and treatment

Simon K.L. Lam, G. S. Ngian, R. Travers, K. K.T. Lim

Research output: Contribution to journal › Article › Other › peer-review

Abstract

In this Grand Round, we present a 58-year-old man with a presumptive diagnosis of rheumatoid arthritis (RA) who was being managed by a plastic surgery unit for a dorsal swelling of his right hand. While awaiting surgery for this lesion, he sustained a pathological fracture of his left neck of femur. This necessitated a total hip joint replacement and pathology revealed amyloidosis. Excision of the hand swelling also revealed amyloidosis as the cause. We discuss the ways in which amyloidosis can mimic musculoskeletal disease as well as the importance and some potential pitfalls of further investigation and management once the diagnosis of amyloidosis has been made.

Original language	English
Pages (from-to)	55-60
Number of pages	6
Journal	International Journal of Rheumatic Diseases
Volume	11
Issue number	1
DOIs	https://doi.org/10.1111/j.1756-185X.2008.00331.x
Publication status	Published - 1 Apr 2008
Externally published	Yes

Keywords

Amyloidosis
Inflammatory arthritis
Pathological fracture
Review

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10.1111/j.1756-185X.2008.00331.x

Cite this

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abstract = "In this Grand Round, we present a 58-year-old man with a presumptive diagnosis of rheumatoid arthritis (RA) who was being managed by a plastic surgery unit for a dorsal swelling of his right hand. While awaiting surgery for this lesion, he sustained a pathological fracture of his left neck of femur. This necessitated a total hip joint replacement and pathology revealed amyloidosis. Excision of the hand swelling also revealed amyloidosis as the cause. We discuss the ways in which amyloidosis can mimic musculoskeletal disease as well as the importance and some potential pitfalls of further investigation and management once the diagnosis of amyloidosis has been made.",

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AB - In this Grand Round, we present a 58-year-old man with a presumptive diagnosis of rheumatoid arthritis (RA) who was being managed by a plastic surgery unit for a dorsal swelling of his right hand. While awaiting surgery for this lesion, he sustained a pathological fracture of his left neck of femur. This necessitated a total hip joint replacement and pathology revealed amyloidosis. Excision of the hand swelling also revealed amyloidosis as the cause. We discuss the ways in which amyloidosis can mimic musculoskeletal disease as well as the importance and some potential pitfalls of further investigation and management once the diagnosis of amyloidosis has been made.

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Amyloidosis: A rheumatological perspective on diagnosis, further investigation and treatment

Abstract

Keywords

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