Amylin: Physiological roles in the kidney and a hypothesis for its role in hypertension

Peter J. Wookey, Mark E. Cooper

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)

Abstract

1. There are high-affinity binding sites for amylin in the renal cortex associated with proximal tubules. These appear to represent seven transmembrane (heptatopic) receptors that are known to form ternary complexes with G-proteins and activate second messenger systems. 2. Amylin stimulates sodium/water reabsorption from the basolateral side of the proximal tubules and plays a role in sodium homeostasis. 3. The transient expression of amylin-like mRNA has been detected perinatally, using in situ hybridization, in the subnephrogenic zone of the metanephros and is associated with proximal tubules of the developing nephron. There it is thought to play a role as a growth factor for brush border epithelial cells in the developing kidney and in renal regrowth in the adult kidney. 4. In two models of hypertension, the spontaneously hypertensive rat (SHR) and one created surgically by subtotal nephrectomy, renal amylin receptors are activated. In the SHR, activation precedes the rise in blood pressure and suggests that activation of the amylin system may be an important event in the development of hypertension.

Original languageEnglish
Pages (from-to)653-660
Number of pages8
JournalClinical and Experimental Pharmacology and Physiology
Volume25
Issue number9
DOIs
Publication statusPublished - 1 Jan 1998
Externally publishedYes

Keywords

  • Amylin
  • Diabetes
  • Growth factors
  • Hypertension
  • Kidney
  • Metanephros
  • Proximal tubules
  • Sodium homeostasis

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