AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder

Andrew Stuart Gibbons, Lucy Brooks, Elizabeth Scarr, Brian Dean

Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Abstract

Glutamate is thought to be involved in the pathophysiology of major depressive disorder and bipolar disorder; however, the molecular changes underlying abnormal glutamatergic signalling remain poorly understood. Whilst previous studies have suggested that the NMDA receptor may be involved in the pathophysiology of mood disorders, it is unclear whether the non-NMDA receptors are also involved. Therefore, we sought to examine whether the expression of the non-NMDA, ionotropic glutamate receptors, AMPA receptor and kainate receptor, is altered in mood disorders.
Original languageEnglish
Pages (from-to)1232 - 1237
Number of pages6
JournalJournal of Affective Disorders
Volume136
Issue number3
DOIs
Publication statusPublished - 2012

Cite this

Gibbons, Andrew Stuart ; Brooks, Lucy ; Scarr, Elizabeth ; Dean, Brian. / AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder. In: Journal of Affective Disorders. 2012 ; Vol. 136, No. 3. pp. 1232 - 1237.
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abstract = "Glutamate is thought to be involved in the pathophysiology of major depressive disorder and bipolar disorder; however, the molecular changes underlying abnormal glutamatergic signalling remain poorly understood. Whilst previous studies have suggested that the NMDA receptor may be involved in the pathophysiology of mood disorders, it is unclear whether the non-NMDA receptors are also involved. Therefore, we sought to examine whether the expression of the non-NMDA, ionotropic glutamate receptors, AMPA receptor and kainate receptor, is altered in mood disorders.",
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Gibbons, AS, Brooks, L, Scarr, E & Dean, B 2012, 'AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder', Journal of Affective Disorders, vol. 136, no. 3, pp. 1232 - 1237. https://doi.org/10.1016/j.jad.2011.10.001

AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder. / Gibbons, Andrew Stuart; Brooks, Lucy; Scarr, Elizabeth; Dean, Brian.

In: Journal of Affective Disorders, Vol. 136, No. 3, 2012, p. 1232 - 1237.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder

AU - Gibbons, Andrew Stuart

AU - Brooks, Lucy

AU - Scarr, Elizabeth

AU - Dean, Brian

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N2 - Glutamate is thought to be involved in the pathophysiology of major depressive disorder and bipolar disorder; however, the molecular changes underlying abnormal glutamatergic signalling remain poorly understood. Whilst previous studies have suggested that the NMDA receptor may be involved in the pathophysiology of mood disorders, it is unclear whether the non-NMDA receptors are also involved. Therefore, we sought to examine whether the expression of the non-NMDA, ionotropic glutamate receptors, AMPA receptor and kainate receptor, is altered in mood disorders.

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DO - 10.1016/j.jad.2011.10.001

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JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

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Gibbons AS, Brooks L, Scarr E, Dean B. AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder. Journal of Affective Disorders. 2012;136(3):1232 - 1237. https://doi.org/10.1016/j.jad.2011.10.001

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