TY - JOUR
T1 - AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder
AU - Gibbons, Andrew Stuart
AU - Brooks, Lucy
AU - Scarr, Elizabeth
AU - Dean, Brian
PY - 2012
Y1 - 2012
N2 - Glutamate is thought to be involved in the pathophysiology of major depressive disorder and bipolar disorder; however, the molecular changes underlying abnormal glutamatergic signalling remain poorly understood. Whilst previous studies have suggested that the NMDA receptor may be involved in the pathophysiology of mood disorders, it is unclear whether the non-NMDA receptors are also involved. Therefore, we sought to examine whether the expression of the non-NMDA, ionotropic glutamate receptors, AMPA receptor and kainate receptor, is altered in mood disorders.
AB - Glutamate is thought to be involved in the pathophysiology of major depressive disorder and bipolar disorder; however, the molecular changes underlying abnormal glutamatergic signalling remain poorly understood. Whilst previous studies have suggested that the NMDA receptor may be involved in the pathophysiology of mood disorders, it is unclear whether the non-NMDA receptors are also involved. Therefore, we sought to examine whether the expression of the non-NMDA, ionotropic glutamate receptors, AMPA receptor and kainate receptor, is altered in mood disorders.
U2 - 10.1016/j.jad.2011.10.001
DO - 10.1016/j.jad.2011.10.001
M3 - Article
VL - 136
SP - 1232
EP - 1237
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 3
ER -