AMP-activated protein kinase (AMPK) activation by benzofurans and coumestans isolated from Erythrina abyssinica

Phi Hung Nguyen, Thi Ngoc Anh Nguyen, Trong Tuan Dao, Hu Won Kang, Derek Tantoh Ndinteh, Joseph Tanyi Mbafor, Won Keun Oh

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42 Citations (Scopus)


AMP-activated protein kinase (AMPK) has been proposed as a therapeutic target for the treatment of metabolic syndrome including obesity and type-2 diabetes. The bioassay-guided fractionation of an EtOAc-soluble extract of the stem bark of Erythrina abyssinica led to the isolation of a new coumestan, erythribyssin N (1), and two new benzofurans, erythribyssin F (2) and erythribyssin H (3), along with five known compounds (4-8). When tested for their stimulatory effects on AMPK activity at a concentration of 10 μM, compounds 4 and 5 showed potent activation, while compounds 1, 2, and 7 had moderate effects. These results suggest that benzofurans and coumestans may be new lead compounds for regulating the AMPK enzyme.

Original languageEnglish
Pages (from-to)598-602
Number of pages5
JournalJournal of Natural Products
Issue number4
Publication statusPublished - 23 Apr 2010
Externally publishedYes

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