Amnion epithelial cells for lung diseases

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Amnion epithelial cells, dervied from the amnion fetal membranes, are pluripotnent and imunomodulatory. They ave been shown to both prevent and repair acute lung injury in a number of diverse experimental models. They are readily isolated from term placentae in sufficient numbers suitable for clinical application. They also have a number of features that make them particularly attractive as a future cell therapy including being immune-privileged and nontumorigenic. This chapter reviews the use of amnion epithelial cells as a cell therapy for lung injury, addressing likely mechanisms of action and future clinical trials.
Original languageEnglish
Title of host publicationPerinatal Stem Cells
EditorsAnthony Atala, Sean V Murphy
Place of PublicationUSA
PublisherSpringer
Pages209 - 217
Number of pages9
Edition1st
ISBN (Print)9781493911172
DOIs
Publication statusPublished - 2014

Cite this

Wallace, E. M., Tan, J., Malhotra, A., Jenkin, G., & Lim, R. S. W. (2014). Amnion epithelial cells for lung diseases. In A. Atala, & S. V. Murphy (Eds.), Perinatal Stem Cells (1st ed., pp. 209 - 217). USA: Springer. https://doi.org/10.1007/978-1-4939-1118-9_19
Wallace, Euan Morrison ; Tan, Jean ; Malhotra, Atul ; Jenkin, Graham ; Lim, Rebecca Seok Wai. / Amnion epithelial cells for lung diseases. Perinatal Stem Cells. editor / Anthony Atala ; Sean V Murphy. 1st. ed. USA : Springer, 2014. pp. 209 - 217
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Wallace, EM, Tan, J, Malhotra, A, Jenkin, G & Lim, RSW 2014, Amnion epithelial cells for lung diseases. in A Atala & SV Murphy (eds), Perinatal Stem Cells. 1st edn, Springer, USA, pp. 209 - 217. https://doi.org/10.1007/978-1-4939-1118-9_19

Amnion epithelial cells for lung diseases. / Wallace, Euan Morrison; Tan, Jean; Malhotra, Atul; Jenkin, Graham; Lim, Rebecca Seok Wai.

Perinatal Stem Cells. ed. / Anthony Atala; Sean V Murphy. 1st. ed. USA : Springer, 2014. p. 209 - 217.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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AB - Amnion epithelial cells, dervied from the amnion fetal membranes, are pluripotnent and imunomodulatory. They ave been shown to both prevent and repair acute lung injury in a number of diverse experimental models. They are readily isolated from term placentae in sufficient numbers suitable for clinical application. They also have a number of features that make them particularly attractive as a future cell therapy including being immune-privileged and nontumorigenic. This chapter reviews the use of amnion epithelial cells as a cell therapy for lung injury, addressing likely mechanisms of action and future clinical trials.

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Wallace EM, Tan J, Malhotra A, Jenkin G, Lim RSW. Amnion epithelial cells for lung diseases. In Atala A, Murphy SV, editors, Perinatal Stem Cells. 1st ed. USA: Springer. 2014. p. 209 - 217 https://doi.org/10.1007/978-1-4939-1118-9_19