Amnion epithelial cells for lung diseases

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Abstract

Amnion epithelial cells, dervied from the amnion fetal membranes, are pluripotnent and imunomodulatory. They ave been shown to both prevent and repair acute lung injury in a number of diverse experimental models. They are readily isolated from term placentae in sufficient numbers suitable for clinical application. They also have a number of features that make them particularly attractive as a future cell therapy including being immune-privileged and nontumorigenic. This chapter reviews the use of amnion epithelial cells as a cell therapy for lung injury, addressing likely mechanisms of action and future clinical trials.
Original languageEnglish
Title of host publicationPerinatal Stem Cells
EditorsAnthony Atala, Sean V Murphy
Place of PublicationUSA
PublisherSpringer
Pages209 - 217
Number of pages9
Edition1st
ISBN (Print)9781493911172
DOIs
Publication statusPublished - 2014

Cite this

Wallace, E. M., Tan, J., Malhotra, A., Jenkin, G., & Lim, R. S. W. (2014). Amnion epithelial cells for lung diseases. In A. Atala, & S. V. Murphy (Eds.), Perinatal Stem Cells (1st ed., pp. 209 - 217). Springer. https://doi.org/10.1007/978-1-4939-1118-9_19