Amnion epithelial cells as a candidate therapy for acute and chronic lung injury

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

Acute and chronic lung injury represents a major and growing global burden of disease. For many of these lung diseases, the damage is irreparable, exhausting the host s ability to regenerate new lung, and current therapies are simply supportive rather than restorative. Cell-based therapies offer the promise of tissue regeneration for many organs. In this paper, we examine the potential application of amnion epithelial cells, derived from the term placenta, to lung regeneration. We discuss their unique properties of plasticity and immunomodulation, reviewing the experimental evidence that amnion epithelial cells can prevent and repair lung injury, offering the potential to be applied to both neonatal, childhood, and adult lung disease. It is amazing to suggest that the placenta may offer renewed life after birth as well as securing new life before.
Original languageEnglish
Article number709763
Number of pages7
JournalStem Cells International
Volume2012
DOIs
Publication statusPublished - 2012

Cite this

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title = "Amnion epithelial cells as a candidate therapy for acute and chronic lung injury",
abstract = "Acute and chronic lung injury represents a major and growing global burden of disease. For many of these lung diseases, the damage is irreparable, exhausting the host s ability to regenerate new lung, and current therapies are simply supportive rather than restorative. Cell-based therapies offer the promise of tissue regeneration for many organs. In this paper, we examine the potential application of amnion epithelial cells, derived from the term placenta, to lung regeneration. We discuss their unique properties of plasticity and immunomodulation, reviewing the experimental evidence that amnion epithelial cells can prevent and repair lung injury, offering the potential to be applied to both neonatal, childhood, and adult lung disease. It is amazing to suggest that the placenta may offer renewed life after birth as well as securing new life before.",
author = "Ryan Hodges and Rebecca Lim and Graham Jenkin and Euan Wallace",
year = "2012",
doi = "10.1155/2012/709763",
language = "English",
volume = "2012",
journal = "Stem Cells International",
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Amnion epithelial cells as a candidate therapy for acute and chronic lung injury. / Hodges, Ryan; Lim, Rebecca; Jenkin, Graham; Wallace, Euan.

In: Stem Cells International, Vol. 2012, 709763, 2012.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Amnion epithelial cells as a candidate therapy for acute and chronic lung injury

AU - Hodges, Ryan

AU - Lim, Rebecca

AU - Jenkin, Graham

AU - Wallace, Euan

PY - 2012

Y1 - 2012

N2 - Acute and chronic lung injury represents a major and growing global burden of disease. For many of these lung diseases, the damage is irreparable, exhausting the host s ability to regenerate new lung, and current therapies are simply supportive rather than restorative. Cell-based therapies offer the promise of tissue regeneration for many organs. In this paper, we examine the potential application of amnion epithelial cells, derived from the term placenta, to lung regeneration. We discuss their unique properties of plasticity and immunomodulation, reviewing the experimental evidence that amnion epithelial cells can prevent and repair lung injury, offering the potential to be applied to both neonatal, childhood, and adult lung disease. It is amazing to suggest that the placenta may offer renewed life after birth as well as securing new life before.

AB - Acute and chronic lung injury represents a major and growing global burden of disease. For many of these lung diseases, the damage is irreparable, exhausting the host s ability to regenerate new lung, and current therapies are simply supportive rather than restorative. Cell-based therapies offer the promise of tissue regeneration for many organs. In this paper, we examine the potential application of amnion epithelial cells, derived from the term placenta, to lung regeneration. We discuss their unique properties of plasticity and immunomodulation, reviewing the experimental evidence that amnion epithelial cells can prevent and repair lung injury, offering the potential to be applied to both neonatal, childhood, and adult lung disease. It is amazing to suggest that the placenta may offer renewed life after birth as well as securing new life before.

UR - http://www.hindawi.com/journals/sci/2012/709763/

U2 - 10.1155/2012/709763

DO - 10.1155/2012/709763

M3 - Article

VL - 2012

JO - Stem Cells International

JF - Stem Cells International

SN - 1687-966X

M1 - 709763

ER -