TY - JOUR
T1 - Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2
T2 - Theoretical, biochemical and practical aspects
AU - Colditz, Michael J.
AU - Leyen, Karin Van
AU - Jeffree, Rosalind L.
PY - 2012/12
Y1 - 2012/12
N2 - The importance of the extent of resection for gliomas, and the utility of aminolevulinic acid (ALA) and protoporphyrin IX fluorescence in increasing the extent of resection, has become increasingly evident over the past decade. This review continues from Part 1 and focuses on the biochemical mechanisms by which ALA ingestion leads to tumour fluorescence, and discusses practicalities of the equipment and techniques needed to introduce ALA and fluorescence guided resection into neurosurgical practice.
AB - The importance of the extent of resection for gliomas, and the utility of aminolevulinic acid (ALA) and protoporphyrin IX fluorescence in increasing the extent of resection, has become increasingly evident over the past decade. This review continues from Part 1 and focuses on the biochemical mechanisms by which ALA ingestion leads to tumour fluorescence, and discusses practicalities of the equipment and techniques needed to introduce ALA and fluorescence guided resection into neurosurgical practice.
KW - Aminolevulinic acid (ALA)
KW - Fluorescence guided resection
KW - Gliolan
KW - Glioma
KW - Protoporphyrin IX
UR - http://www.scopus.com/inward/record.url?scp=84868302839&partnerID=8YFLogxK
U2 - 10.1016/j.jocn.2012.03.013
DO - 10.1016/j.jocn.2012.03.013
M3 - Review Article
C2 - 23059058
AN - SCOPUS:84868302839
SN - 0967-5868
VL - 19
SP - 1611
EP - 1616
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
IS - 12
ER -