Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension

Felix Mahfoud; Christian Ukena; Roland E Schmieder; Bodo Cremers; Lars C Rump; Oliver Vonend; Joachim Weil; Martin Schmidt; Uta C Hoppe; Thomas Zeller; Axel Bauer; Christiane Otto; Erwin Blessing; Paul Sobotka; Henry Krum; Markus Peter Schlaich; Murray D Esler; Michael Bohm

doi:10.1161/CIRCULATIONAHA.112.000949

Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension

Felix Mahfoud, Christian Ukena, Roland E Schmieder, Bodo Cremers, Lars C Rump, Oliver Vonend, Joachim Weil, Martin Schmidt, Uta C Hoppe, Thomas Zeller, Axel Bauer, Christiane Otto, Erwin Blessing, Paul Sobotka, Henry Krum, Markus Peter Schlaich, Murray D Esler, Michael Bohm

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

235 Citations (Scopus)

Abstract

Catheter-based renal sympathetic denervation (RDN) reduces office blood pressure (BP) in patients with resistant hypertension according to office BP. Less is known about the effect of RDN on 24-hour BP measured by ambulatory BP monitoring and correlates of response in individuals with true or pseudoresistant hypertension. Methods and Results-A total of 346 uncontrolled hypertensive patients, separated according to daytime ambulatory BP monitoring into 303 with true resistant (office systolic BP [SBP] 172.2?22 mm Hg; 24-hour SBP 154?16.2 mm Hg) and 43 with pseudoresistant hypertension (office SBP 161.2?20.3 mm Hg; 24-hour SBP 121.1?19.6 mm Hg), from 10 centers were studied. At 3, 6, and 12 months follow-up, office SBP was reduced by 21.5/23.7/27.3 mm Hg, office diastolic BP by 8.9/9.5/11.7 mm Hg, and pulse pressure by 13.4/14.2/14.9 mm Hg (n=245/236/90; P for all

Original language	English
Pages (from-to)	132 - 140
Number of pages	9
Journal	Circulation
Volume	128
Issue number	2
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.112.000949
Publication status	Published - 2013

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Mahfoud, F., Ukena, C., Schmieder, R. E., Cremers, B., Rump, L. C., Vonend, O., Weil, J., Schmidt, M., Hoppe, U. C., Zeller, T., Bauer, A., Otto, C., Blessing, E., Sobotka, P., Krum, H., Schlaich, M. P., Esler, M. D., & Bohm, M. (2013). Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension. Circulation, 128(2), 132 - 140. https://doi.org/10.1161/CIRCULATIONAHA.112.000949

@article{112d5784bb574066a10454b3319fe89e,

title = "Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension",

abstract = "Catheter-based renal sympathetic denervation (RDN) reduces office blood pressure (BP) in patients with resistant hypertension according to office BP. Less is known about the effect of RDN on 24-hour BP measured by ambulatory BP monitoring and correlates of response in individuals with true or pseudoresistant hypertension. Methods and Results-A total of 346 uncontrolled hypertensive patients, separated according to daytime ambulatory BP monitoring into 303 with true resistant (office systolic BP [SBP] 172.2?22 mm Hg; 24-hour SBP 154?16.2 mm Hg) and 43 with pseudoresistant hypertension (office SBP 161.2?20.3 mm Hg; 24-hour SBP 121.1?19.6 mm Hg), from 10 centers were studied. At 3, 6, and 12 months follow-up, office SBP was reduced by 21.5/23.7/27.3 mm Hg, office diastolic BP by 8.9/9.5/11.7 mm Hg, and pulse pressure by 13.4/14.2/14.9 mm Hg (n=245/236/90; P for all",

author = "Felix Mahfoud and Christian Ukena and Schmieder, {Roland E} and Bodo Cremers and Rump, {Lars C} and Oliver Vonend and Joachim Weil and Martin Schmidt and Hoppe, {Uta C} and Thomas Zeller and Axel Bauer and Christiane Otto and Erwin Blessing and Paul Sobotka and Henry Krum and Schlaich, {Markus Peter} and Esler, {Murray D} and Michael Bohm",

year = "2013",

doi = "10.1161/CIRCULATIONAHA.112.000949",

language = "English",

volume = "128",

pages = "132 -- 140",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams & Wilkins",

number = "2",

}

Mahfoud, F, Ukena, C, Schmieder, RE, Cremers, B, Rump, LC, Vonend, O, Weil, J, Schmidt, M, Hoppe, UC, Zeller, T, Bauer, A, Otto, C, Blessing, E, Sobotka, P, Krum, H, Schlaich, MP, Esler, MD & Bohm, M 2013, 'Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension', Circulation, vol. 128, no. 2, pp. 132 - 140. https://doi.org/10.1161/CIRCULATIONAHA.112.000949

TY - JOUR

T1 - Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension

AU - Mahfoud, Felix

AU - Ukena, Christian

AU - Schmieder, Roland E

AU - Cremers, Bodo

AU - Rump, Lars C

AU - Vonend, Oliver

AU - Weil, Joachim

AU - Schmidt, Martin

AU - Hoppe, Uta C

AU - Zeller, Thomas

AU - Bauer, Axel

AU - Otto, Christiane

AU - Blessing, Erwin

AU - Sobotka, Paul

AU - Krum, Henry

AU - Schlaich, Markus Peter

AU - Esler, Murray D

AU - Bohm, Michael

PY - 2013

Y1 - 2013

N2 - Catheter-based renal sympathetic denervation (RDN) reduces office blood pressure (BP) in patients with resistant hypertension according to office BP. Less is known about the effect of RDN on 24-hour BP measured by ambulatory BP monitoring and correlates of response in individuals with true or pseudoresistant hypertension. Methods and Results-A total of 346 uncontrolled hypertensive patients, separated according to daytime ambulatory BP monitoring into 303 with true resistant (office systolic BP [SBP] 172.2?22 mm Hg; 24-hour SBP 154?16.2 mm Hg) and 43 with pseudoresistant hypertension (office SBP 161.2?20.3 mm Hg; 24-hour SBP 121.1?19.6 mm Hg), from 10 centers were studied. At 3, 6, and 12 months follow-up, office SBP was reduced by 21.5/23.7/27.3 mm Hg, office diastolic BP by 8.9/9.5/11.7 mm Hg, and pulse pressure by 13.4/14.2/14.9 mm Hg (n=245/236/90; P for all

AB - Catheter-based renal sympathetic denervation (RDN) reduces office blood pressure (BP) in patients with resistant hypertension according to office BP. Less is known about the effect of RDN on 24-hour BP measured by ambulatory BP monitoring and correlates of response in individuals with true or pseudoresistant hypertension. Methods and Results-A total of 346 uncontrolled hypertensive patients, separated according to daytime ambulatory BP monitoring into 303 with true resistant (office systolic BP [SBP] 172.2?22 mm Hg; 24-hour SBP 154?16.2 mm Hg) and 43 with pseudoresistant hypertension (office SBP 161.2?20.3 mm Hg; 24-hour SBP 121.1?19.6 mm Hg), from 10 centers were studied. At 3, 6, and 12 months follow-up, office SBP was reduced by 21.5/23.7/27.3 mm Hg, office diastolic BP by 8.9/9.5/11.7 mm Hg, and pulse pressure by 13.4/14.2/14.9 mm Hg (n=245/236/90; P for all

UR - http://circ.ahajournals.org/content/128/2/132.full.pdf

U2 - 10.1161/CIRCULATIONAHA.112.000949

DO - 10.1161/CIRCULATIONAHA.112.000949

M3 - Article

SN - 0009-7322

VL - 128

SP - 132

EP - 140

JO - Circulation

JF - Circulation

IS - 2

ER -

Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension

Abstract

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