Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension

Felix Mahfoud, Christian Ukena, Roland E Schmieder, Bodo Cremers, Lars C Rump, Oliver Vonend, Joachim Weil, Martin Schmidt, Uta C Hoppe, Thomas Zeller, Axel Bauer, Christiane Otto, Erwin Blessing, Paul Sobotka, Henry Krum, Markus Peter Schlaich, Murray D Esler, Michael Bohm

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217 Citations (Scopus)

Abstract

Catheter-based renal sympathetic denervation (RDN) reduces office blood pressure (BP) in patients with resistant hypertension according to office BP. Less is known about the effect of RDN on 24-hour BP measured by ambulatory BP monitoring and correlates of response in individuals with true or pseudoresistant hypertension. Methods and Results-A total of 346 uncontrolled hypertensive patients, separated according to daytime ambulatory BP monitoring into 303 with true resistant (office systolic BP [SBP] 172.2?22 mm Hg; 24-hour SBP 154?16.2 mm Hg) and 43 with pseudoresistant hypertension (office SBP 161.2?20.3 mm Hg; 24-hour SBP 121.1?19.6 mm Hg), from 10 centers were studied. At 3, 6, and 12 months follow-up, office SBP was reduced by 21.5/23.7/27.3 mm Hg, office diastolic BP by 8.9/9.5/11.7 mm Hg, and pulse pressure by 13.4/14.2/14.9 mm Hg (n=245/236/90; P for all
Original languageEnglish
Pages (from-to)132 - 140
Number of pages9
JournalCirculation
Volume128
Issue number2
DOIs
Publication statusPublished - 2013

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