Ambient PM1 air pollution, blood pressure, and hypertension

Insights from the 33 Communities Chinese Health Study

Bo Yi Yang, Yuming Guo, Michael S. Bloom, Xiang Xiao, Zhengmin (Min) Qian, Echu Liu, Steven W. Howard, Tianyu Zhao, Si Quan Wang, Shanshan Li, Duo Hong Chen, Huimin Ma, Steve Hung Lam Yim, Kang Kang Liu, Xiao Wen Zeng, Li Wen Hu, Ru Qing Liu, Dan Feng, Mo Yang, Shu Li Xu & 1 others Guang Hui Dong

Research output: Contribution to journalArticleResearchpeer-review

Abstract

No evidence exists concerning the association between blood pressure and ambient particles with aerodynamic diameter ≤ 1.0 µm (PM1), a major component of PM2.5 (≤ 2.5 µm) particles, and potentially causing more hazardous health effects than PM2.5. We aimed to examine the associations of blood pressure in adults with both PM1 and PM2.5 in China. In 2009, we randomly selected 24,845 participants aged 18–74 years from 33 communities in China. Using a standardized mercuric-column sphygmomanometer, we measured blood pressure. Long-term exposure (2006–08) to PM1 and PM2.5 were estimated using a spatial statistical model. Generalized linear mixed models were used to evaluate the associations between air pollutants and blood pressure and hypertension prevalence, controlling for multiple covariates. A 10-μg/m3 increase in PM1 was significantly associated with an increase of 0.57 (95% CI 0.31–0.83) mmHg in systolic blood pressure (SBP), 0.19 (95% CI 0.03–0.35) mmHg increase in diastolic blood pressure (DBP), and a 5% (OR=1.05; 95% CI 1.01–1.10) increase in odds for hypertension. Similar associations were detected for PM2.5. Furthermore, PM1–2.5 showed no association with blood pressure or hypertension. In summary, both PM1 and PM2.5 exposures were associated with elevated blood pressure levels and hypertension prevalence in Chinese adults. In addition, most of the pro-hypertensive effects of PM2.5 may come from PM1. Further longitudinal designed studies are warranted to validate our findings.

Original languageEnglish
Pages (from-to)252-259
Number of pages8
JournalEnvironmental Research
Volume170
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • Adults
  • Cross-sectional study
  • Diastolic blood pressure
  • Particulate matter
  • Systolic blood pressure

Cite this

Yang, Bo Yi ; Guo, Yuming ; Bloom, Michael S. ; Xiao, Xiang ; Qian, Zhengmin (Min) ; Liu, Echu ; Howard, Steven W. ; Zhao, Tianyu ; Wang, Si Quan ; Li, Shanshan ; Chen, Duo Hong ; Ma, Huimin ; Yim, Steve Hung Lam ; Liu, Kang Kang ; Zeng, Xiao Wen ; Hu, Li Wen ; Liu, Ru Qing ; Feng, Dan ; Yang, Mo ; Xu, Shu Li ; Dong, Guang Hui. / Ambient PM1 air pollution, blood pressure, and hypertension : Insights from the 33 Communities Chinese Health Study. In: Environmental Research. 2019 ; Vol. 170. pp. 252-259.
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title = "Ambient PM1 air pollution, blood pressure, and hypertension: Insights from the 33 Communities Chinese Health Study",
abstract = "No evidence exists concerning the association between blood pressure and ambient particles with aerodynamic diameter ≤ 1.0 µm (PM1), a major component of PM2.5 (≤ 2.5 µm) particles, and potentially causing more hazardous health effects than PM2.5. We aimed to examine the associations of blood pressure in adults with both PM1 and PM2.5 in China. In 2009, we randomly selected 24,845 participants aged 18–74 years from 33 communities in China. Using a standardized mercuric-column sphygmomanometer, we measured blood pressure. Long-term exposure (2006–08) to PM1 and PM2.5 were estimated using a spatial statistical model. Generalized linear mixed models were used to evaluate the associations between air pollutants and blood pressure and hypertension prevalence, controlling for multiple covariates. A 10-μg/m3 increase in PM1 was significantly associated with an increase of 0.57 (95{\%} CI 0.31–0.83) mmHg in systolic blood pressure (SBP), 0.19 (95{\%} CI 0.03–0.35) mmHg increase in diastolic blood pressure (DBP), and a 5{\%} (OR=1.05; 95{\%} CI 1.01–1.10) increase in odds for hypertension. Similar associations were detected for PM2.5. Furthermore, PM1–2.5 showed no association with blood pressure or hypertension. In summary, both PM1 and PM2.5 exposures were associated with elevated blood pressure levels and hypertension prevalence in Chinese adults. In addition, most of the pro-hypertensive effects of PM2.5 may come from PM1. Further longitudinal designed studies are warranted to validate our findings.",
keywords = "Adults, Cross-sectional study, Diastolic blood pressure, Particulate matter, Systolic blood pressure",
author = "Yang, {Bo Yi} and Yuming Guo and Bloom, {Michael S.} and Xiang Xiao and Qian, {Zhengmin (Min)} and Echu Liu and Howard, {Steven W.} and Tianyu Zhao and Wang, {Si Quan} and Shanshan Li and Chen, {Duo Hong} and Huimin Ma and Yim, {Steve Hung Lam} and Liu, {Kang Kang} and Zeng, {Xiao Wen} and Hu, {Li Wen} and Liu, {Ru Qing} and Dan Feng and Mo Yang and Xu, {Shu Li} and Dong, {Guang Hui}",
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Yang, BY, Guo, Y, Bloom, MS, Xiao, X, Qian, ZM, Liu, E, Howard, SW, Zhao, T, Wang, SQ, Li, S, Chen, DH, Ma, H, Yim, SHL, Liu, KK, Zeng, XW, Hu, LW, Liu, RQ, Feng, D, Yang, M, Xu, SL & Dong, GH 2019, 'Ambient PM1 air pollution, blood pressure, and hypertension: Insights from the 33 Communities Chinese Health Study', Environmental Research, vol. 170, pp. 252-259. https://doi.org/10.1016/j.envres.2018.12.047

Ambient PM1 air pollution, blood pressure, and hypertension : Insights from the 33 Communities Chinese Health Study. / Yang, Bo Yi; Guo, Yuming; Bloom, Michael S.; Xiao, Xiang; Qian, Zhengmin (Min); Liu, Echu; Howard, Steven W.; Zhao, Tianyu; Wang, Si Quan; Li, Shanshan; Chen, Duo Hong; Ma, Huimin; Yim, Steve Hung Lam; Liu, Kang Kang; Zeng, Xiao Wen; Hu, Li Wen; Liu, Ru Qing; Feng, Dan; Yang, Mo; Xu, Shu Li; Dong, Guang Hui.

In: Environmental Research, Vol. 170, 01.03.2019, p. 252-259.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Ambient PM1 air pollution, blood pressure, and hypertension

T2 - Insights from the 33 Communities Chinese Health Study

AU - Yang, Bo Yi

AU - Guo, Yuming

AU - Bloom, Michael S.

AU - Xiao, Xiang

AU - Qian, Zhengmin (Min)

AU - Liu, Echu

AU - Howard, Steven W.

AU - Zhao, Tianyu

AU - Wang, Si Quan

AU - Li, Shanshan

AU - Chen, Duo Hong

AU - Ma, Huimin

AU - Yim, Steve Hung Lam

AU - Liu, Kang Kang

AU - Zeng, Xiao Wen

AU - Hu, Li Wen

AU - Liu, Ru Qing

AU - Feng, Dan

AU - Yang, Mo

AU - Xu, Shu Li

AU - Dong, Guang Hui

PY - 2019/3/1

Y1 - 2019/3/1

N2 - No evidence exists concerning the association between blood pressure and ambient particles with aerodynamic diameter ≤ 1.0 µm (PM1), a major component of PM2.5 (≤ 2.5 µm) particles, and potentially causing more hazardous health effects than PM2.5. We aimed to examine the associations of blood pressure in adults with both PM1 and PM2.5 in China. In 2009, we randomly selected 24,845 participants aged 18–74 years from 33 communities in China. Using a standardized mercuric-column sphygmomanometer, we measured blood pressure. Long-term exposure (2006–08) to PM1 and PM2.5 were estimated using a spatial statistical model. Generalized linear mixed models were used to evaluate the associations between air pollutants and blood pressure and hypertension prevalence, controlling for multiple covariates. A 10-μg/m3 increase in PM1 was significantly associated with an increase of 0.57 (95% CI 0.31–0.83) mmHg in systolic blood pressure (SBP), 0.19 (95% CI 0.03–0.35) mmHg increase in diastolic blood pressure (DBP), and a 5% (OR=1.05; 95% CI 1.01–1.10) increase in odds for hypertension. Similar associations were detected for PM2.5. Furthermore, PM1–2.5 showed no association with blood pressure or hypertension. In summary, both PM1 and PM2.5 exposures were associated with elevated blood pressure levels and hypertension prevalence in Chinese adults. In addition, most of the pro-hypertensive effects of PM2.5 may come from PM1. Further longitudinal designed studies are warranted to validate our findings.

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KW - Adults

KW - Cross-sectional study

KW - Diastolic blood pressure

KW - Particulate matter

KW - Systolic blood pressure

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