Ambient PM1 air pollution and cardiovascular disease prevalence

Insights from the 33 Communities Chinese Health Study

Bo Yi Yang, Yuming Guo, Lidia Morawska, Michael S. Bloom, Iana Markevych, Joachim Heinrich, Shyamali C. Dharmage, Luke D. Knibbs, Shao Lin, Steve Hung Lam Yim, Gongbo Chen, Shanshan Li, Xiao Wen Zeng, Kang Kang Liu, Li Wen Hu, Guang Hui Dong

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Backgrounds: Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM1 (≤1.0 μm) size fraction and CVD. We investigated the associations between PM1 and PM2.5 and CVD prevalence in Chinese adults. Methods: In 2009, we randomly recruited 24,845 adults at the age of 18–74 years from 33 communities in Northeastern China. CVD status was determined by self-report of doctor-diagnosed CVD. Three-year (2006–08) average concentrations of PM1 and PM2.5 were assigned using a satellite-based exposure. We used spatial Generalized Linear Mixed Models to evaluate the associations between air pollutants and CVD prevalence, adjusting for multiple covariates. Stratified and interaction analyses and sensitivity analyses were also performed. Results: A 10 μg/m3 increase in long-term exposure to ambient PM1 levels was associated a 12% higher odds for having CVD (OR = 1.12; 95% CI = 1.05–1.20). Compared to PM1, association between PM2.5 and CVD was lower (OR = 1.06; 95% CI = 1.01–1.11). No significant association was observed for PM1–2.5 (1–2.5 μm) size fraction (OR = 0.98; 95% CI = 0.85–1.13). Stratified analyses showed greater effect estimates in men and the elder. Conclusions: Long-term PM1 exposure was positively related to CVD, especially in men and the elder. In addition, PM1 may play a greater role than PM2.5 in associations with CVD. Further longitudinal studies are warranted to confirm our findings.

Original languageEnglish
Pages (from-to)310-317
Number of pages8
JournalEnvironment International
Volume123
DOIs
Publication statusPublished - 1 Feb 2019

Keywords

  • Adults
  • Cardiovascular disease
  • Chinese
  • Cross-sectional study
  • Particulate matter

Cite this

Yang, Bo Yi ; Guo, Yuming ; Morawska, Lidia ; Bloom, Michael S. ; Markevych, Iana ; Heinrich, Joachim ; Dharmage, Shyamali C. ; Knibbs, Luke D. ; Lin, Shao ; Yim, Steve Hung Lam ; Chen, Gongbo ; Li, Shanshan ; Zeng, Xiao Wen ; Liu, Kang Kang ; Hu, Li Wen ; Dong, Guang Hui. / Ambient PM1 air pollution and cardiovascular disease prevalence : Insights from the 33 Communities Chinese Health Study. In: Environment International. 2019 ; Vol. 123. pp. 310-317.
@article{5706cd5e2ee24bf887cf5a80f3617fdc,
title = "Ambient PM1 air pollution and cardiovascular disease prevalence: Insights from the 33 Communities Chinese Health Study",
abstract = "Backgrounds: Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM1 (≤1.0 μm) size fraction and CVD. We investigated the associations between PM1 and PM2.5 and CVD prevalence in Chinese adults. Methods: In 2009, we randomly recruited 24,845 adults at the age of 18–74 years from 33 communities in Northeastern China. CVD status was determined by self-report of doctor-diagnosed CVD. Three-year (2006–08) average concentrations of PM1 and PM2.5 were assigned using a satellite-based exposure. We used spatial Generalized Linear Mixed Models to evaluate the associations between air pollutants and CVD prevalence, adjusting for multiple covariates. Stratified and interaction analyses and sensitivity analyses were also performed. Results: A 10 μg/m3 increase in long-term exposure to ambient PM1 levels was associated a 12{\%} higher odds for having CVD (OR = 1.12; 95{\%} CI = 1.05–1.20). Compared to PM1, association between PM2.5 and CVD was lower (OR = 1.06; 95{\%} CI = 1.01–1.11). No significant association was observed for PM1–2.5 (1–2.5 μm) size fraction (OR = 0.98; 95{\%} CI = 0.85–1.13). Stratified analyses showed greater effect estimates in men and the elder. Conclusions: Long-term PM1 exposure was positively related to CVD, especially in men and the elder. In addition, PM1 may play a greater role than PM2.5 in associations with CVD. Further longitudinal studies are warranted to confirm our findings.",
keywords = "Adults, Cardiovascular disease, Chinese, Cross-sectional study, Particulate matter",
author = "Yang, {Bo Yi} and Yuming Guo and Lidia Morawska and Bloom, {Michael S.} and Iana Markevych and Joachim Heinrich and Dharmage, {Shyamali C.} and Knibbs, {Luke D.} and Shao Lin and Yim, {Steve Hung Lam} and Gongbo Chen and Shanshan Li and Zeng, {Xiao Wen} and Liu, {Kang Kang} and Hu, {Li Wen} and Dong, {Guang Hui}",
year = "2019",
month = "2",
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Yang, BY, Guo, Y, Morawska, L, Bloom, MS, Markevych, I, Heinrich, J, Dharmage, SC, Knibbs, LD, Lin, S, Yim, SHL, Chen, G, Li, S, Zeng, XW, Liu, KK, Hu, LW & Dong, GH 2019, 'Ambient PM1 air pollution and cardiovascular disease prevalence: Insights from the 33 Communities Chinese Health Study', Environment International, vol. 123, pp. 310-317. https://doi.org/10.1016/j.envint.2018.12.012

Ambient PM1 air pollution and cardiovascular disease prevalence : Insights from the 33 Communities Chinese Health Study. / Yang, Bo Yi; Guo, Yuming; Morawska, Lidia; Bloom, Michael S.; Markevych, Iana; Heinrich, Joachim; Dharmage, Shyamali C.; Knibbs, Luke D.; Lin, Shao; Yim, Steve Hung Lam; Chen, Gongbo; Li, Shanshan; Zeng, Xiao Wen; Liu, Kang Kang; Hu, Li Wen; Dong, Guang Hui.

In: Environment International, Vol. 123, 01.02.2019, p. 310-317.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Ambient PM1 air pollution and cardiovascular disease prevalence

T2 - Insights from the 33 Communities Chinese Health Study

AU - Yang, Bo Yi

AU - Guo, Yuming

AU - Morawska, Lidia

AU - Bloom, Michael S.

AU - Markevych, Iana

AU - Heinrich, Joachim

AU - Dharmage, Shyamali C.

AU - Knibbs, Luke D.

AU - Lin, Shao

AU - Yim, Steve Hung Lam

AU - Chen, Gongbo

AU - Li, Shanshan

AU - Zeng, Xiao Wen

AU - Liu, Kang Kang

AU - Hu, Li Wen

AU - Dong, Guang Hui

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Backgrounds: Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM1 (≤1.0 μm) size fraction and CVD. We investigated the associations between PM1 and PM2.5 and CVD prevalence in Chinese adults. Methods: In 2009, we randomly recruited 24,845 adults at the age of 18–74 years from 33 communities in Northeastern China. CVD status was determined by self-report of doctor-diagnosed CVD. Three-year (2006–08) average concentrations of PM1 and PM2.5 were assigned using a satellite-based exposure. We used spatial Generalized Linear Mixed Models to evaluate the associations between air pollutants and CVD prevalence, adjusting for multiple covariates. Stratified and interaction analyses and sensitivity analyses were also performed. Results: A 10 μg/m3 increase in long-term exposure to ambient PM1 levels was associated a 12% higher odds for having CVD (OR = 1.12; 95% CI = 1.05–1.20). Compared to PM1, association between PM2.5 and CVD was lower (OR = 1.06; 95% CI = 1.01–1.11). No significant association was observed for PM1–2.5 (1–2.5 μm) size fraction (OR = 0.98; 95% CI = 0.85–1.13). Stratified analyses showed greater effect estimates in men and the elder. Conclusions: Long-term PM1 exposure was positively related to CVD, especially in men and the elder. In addition, PM1 may play a greater role than PM2.5 in associations with CVD. Further longitudinal studies are warranted to confirm our findings.

AB - Backgrounds: Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM1 (≤1.0 μm) size fraction and CVD. We investigated the associations between PM1 and PM2.5 and CVD prevalence in Chinese adults. Methods: In 2009, we randomly recruited 24,845 adults at the age of 18–74 years from 33 communities in Northeastern China. CVD status was determined by self-report of doctor-diagnosed CVD. Three-year (2006–08) average concentrations of PM1 and PM2.5 were assigned using a satellite-based exposure. We used spatial Generalized Linear Mixed Models to evaluate the associations between air pollutants and CVD prevalence, adjusting for multiple covariates. Stratified and interaction analyses and sensitivity analyses were also performed. Results: A 10 μg/m3 increase in long-term exposure to ambient PM1 levels was associated a 12% higher odds for having CVD (OR = 1.12; 95% CI = 1.05–1.20). Compared to PM1, association between PM2.5 and CVD was lower (OR = 1.06; 95% CI = 1.01–1.11). No significant association was observed for PM1–2.5 (1–2.5 μm) size fraction (OR = 0.98; 95% CI = 0.85–1.13). Stratified analyses showed greater effect estimates in men and the elder. Conclusions: Long-term PM1 exposure was positively related to CVD, especially in men and the elder. In addition, PM1 may play a greater role than PM2.5 in associations with CVD. Further longitudinal studies are warranted to confirm our findings.

KW - Adults

KW - Cardiovascular disease

KW - Chinese

KW - Cross-sectional study

KW - Particulate matter

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U2 - 10.1016/j.envint.2018.12.012

DO - 10.1016/j.envint.2018.12.012

M3 - Article

VL - 123

SP - 310

EP - 317

JO - Environment International

JF - Environment International

SN - 0160-4120

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