Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms.

Colin L. Masters; Ben Gu; Simon Laws; Yen Y. Lim; Blaine Roberts; Victor L. Villemagne; Konrad Beyreuther

doi:10.1016/B978-0-12-811304-2.00003-1

Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms.

Colin L. Masters, Ben Gu, Simon Laws, Yen Y. Lim, Blaine Roberts, Victor L. Villemagne, Konrad Beyreuther

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

2 Citations (Scopus)

Abstract

Alzheimer's disease remains a major therapeutic challenge despite a massive research effort over the past two decades. Applying quantitative mechanistic approaches to understanding the quantities and rates of Aβ amyloid production, accumulation and clearance may provide novel and more rigorous insights into developing rational therapeutic strategies.

Original language	English
Title of host publication	The Molecular and Cellular Basis of Neurodegenerative Diseases
Subtitle of host publication	Underlying Mechanisms
Editors	Michael S. Wolfe
Place of Publication	London, UK
Publisher	Academic Press
Chapter	3
Pages	57-79
Number of pages	23
ISBN (Electronic)	9780128113059
ISBN (Print)	9780128113042
DOIs	https://doi.org/10.1016/B978-0-12-811304-2.00003-1
Publication status	Published - 2018
Externally published	Yes

Keywords

Accumulation, and clearance
Alzheimer's disease
Aβ-amyloid
Rates of production

Access to Document

10.1016/B978-0-12-811304-2.00003-1

Cite this

Masters, C. L., Gu, B., Laws, S., Lim, Y. Y., Roberts, B., Villemagne, V. L., & Beyreuther, K. (2018). Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. In M. S. Wolfe (Ed.), The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms (pp. 57-79). Academic Press. https://doi.org/10.1016/B978-0-12-811304-2.00003-1

Masters, Colin L. ; Gu, Ben ; Laws, Simon et al. / Alzheimer's Disease : Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms. editor / Michael S. Wolfe. London, UK : Academic Press, 2018. pp. 57-79

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title = "Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms.",

abstract = "Alzheimer's disease remains a major therapeutic challenge despite a massive research effort over the past two decades. Applying quantitative mechanistic approaches to understanding the quantities and rates of Aβ amyloid production, accumulation and clearance may provide novel and more rigorous insights into developing rational therapeutic strategies.",

keywords = "Accumulation, and clearance, Alzheimer's disease, Aβ-amyloid, Rates of production",

author = "Masters, {Colin L.} and Ben Gu and Simon Laws and Lim, {Yen Y.} and Blaine Roberts and Villemagne, {Victor L.} and Konrad Beyreuther",

year = "2018",

doi = "10.1016/B978-0-12-811304-2.00003-1",

language = "English",

isbn = "9780128113042",

pages = "57--79",

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booktitle = "The Molecular and Cellular Basis of Neurodegenerative Diseases",

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Masters, CL, Gu, B, Laws, S, Lim, YY, Roberts, B, Villemagne, VL & Beyreuther, K 2018, Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. in MS Wolfe (ed.), The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms. Academic Press, London, UK, pp. 57-79. https://doi.org/10.1016/B978-0-12-811304-2.00003-1

Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. / Masters, Colin L.; Gu, Ben; Laws, Simon et al.
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms. ed. / Michael S. Wolfe. London, UK: Academic Press, 2018. p. 57-79.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

TY - CHAP

T1 - Alzheimer's Disease

T2 - Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms.

AU - Masters, Colin L.

AU - Gu, Ben

AU - Laws, Simon

AU - Lim, Yen Y.

AU - Roberts, Blaine

AU - Villemagne, Victor L.

AU - Beyreuther, Konrad

PY - 2018

Y1 - 2018

N2 - Alzheimer's disease remains a major therapeutic challenge despite a massive research effort over the past two decades. Applying quantitative mechanistic approaches to understanding the quantities and rates of Aβ amyloid production, accumulation and clearance may provide novel and more rigorous insights into developing rational therapeutic strategies.

AB - Alzheimer's disease remains a major therapeutic challenge despite a massive research effort over the past two decades. Applying quantitative mechanistic approaches to understanding the quantities and rates of Aβ amyloid production, accumulation and clearance may provide novel and more rigorous insights into developing rational therapeutic strategies.

KW - Accumulation, and clearance

KW - Alzheimer's disease

KW - Aβ-amyloid

KW - Rates of production

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DO - 10.1016/B978-0-12-811304-2.00003-1

M3 - Chapter (Book)

AN - SCOPUS:85054406357

SN - 9780128113042

SP - 57

EP - 79

BT - The Molecular and Cellular Basis of Neurodegenerative Diseases

A2 - Wolfe, Michael S.

PB - Academic Press

CY - London, UK

ER -

Masters CL, Gu B, Laws S, Lim YY, Roberts B, Villemagne VL et al. Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. In Wolfe MS, editor, The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms. London, UK: Academic Press. 2018. p. 57-79 doi: 10.1016/B978-0-12-811304-2.00003-1

Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms. Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms.

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Keywords

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