Alzheimer’s disease and natural products: Future regimens emerging from nature

Md Asiful Islam, Shahad Saif Khandker, Fahmida Alam, Md Ibrahim Khalil, Mohammad Amjad Kamal, Siew Hua Gan

Research output: Contribution to journalReview ArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Alzheimer’s disease (AD), which largely affects the elderly, has become a global burden. Patients with AD have both short- and long-term memory impairments. The neuronal loss in AD occurs due to abnormally folded amyloid beta proteins and aggregation of hyperphosphorylated tau proteins in the brain. Eventually, amyloid plaques and neurofibrillary tangles are formed, which subsequently disintegrate the neuronal transport system. There are several factors which are involved in AD pathogenesis, including oxidative stress, inflammation and the presence of metal ions. The modern therapies utilized for AD treatment have many adverse effects, driving the quest for more safe and effective medications. Many dietary components, including different types of fruits, vegetables, spices, and marine products as well as a Mediterranean diet, are a good source of antioxidants and have anti-inflammatory properties, with many showing substantial potential against AD pathogenesis. In this review, we discuss the potential of these foods for treating AD and opportunities for developing disease-targeted drugs from active compounds extracted from natural dietary products.

Original languageEnglish
Pages (from-to)1408-1428
Number of pages21
JournalCurrent Topics in Medicinal Chemistry
Volume17
Issue number12
DOIs
Publication statusPublished - 1 Apr 2017
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • Drinks
  • Fruits
  • Mediterranean diet
  • Natural products
  • Spices
  • Treatment
  • Vegetables

Cite this