Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression

Minna Liisa Änkö, Maria Östergård, Minnamaija Lintunen, Pertti Panula

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Alternative splicing has an important role in the tissue-specific regulation of gene expression. Here we report that similar to the human NPFF2 receptor, the mouse NPFF2 receptor is alternatively spliced. In human the presence of three alternatively spliced receptor variants were verified, whereas two NPFF2 receptor variants were identified in mouse. The alternative splicing affected the 5′ untranslated region of the mouse receptor and the variants in mouse were differently distributed. The mouse NPFF system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat.

Original languageEnglish
Pages (from-to)6955-6960
Number of pages6
JournalFEBS Letters
Issue number30
Publication statusPublished - 22 Dec 2006
Externally publishedYes


  • Alternative splicing
  • Neuropeptide
  • Neuropeptide FF2 receptor

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