Alternative polyadenylation in the regulation and dysregulation of gene expression

Rachael Emily Turner, Andrew David Pattison, Traude Helene Beilharz

Research output: Contribution to journalArticleOtherpeer-review

28 Citations (Scopus)

Abstract

Transcriptional control shapes a cell's transcriptome composition, but it is RNA processing that refines its expression. The untranslated regions (UTRs) of mRNA are hotspots for regulatory control. Features in these can impact mRNA stability, localisation and translation. Here we describe how alternative cleavage and polyadenylation can change mRNA fate by changing the length of its 3'UTR.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume75
DOIs
Publication statusPublished - Mar 2018

Keywords

  • 3'-End formation
  • 3'UTR
  • Alternative polyadenylation
  • Poly(A)-tail

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