TY - JOUR
T1 - Alternative polyadenylation in the regulation and dysregulation of gene expression
AU - Turner, Rachael Emily
AU - Pattison, Andrew David
AU - Beilharz, Traude Helene
PY - 2018/3
Y1 - 2018/3
N2 - Transcriptional control shapes a cell's transcriptome composition, but it is RNA processing that refines its expression. The untranslated regions (UTRs) of mRNA are hotspots for regulatory control. Features in these can impact mRNA stability, localisation and translation. Here we describe how alternative cleavage and polyadenylation can change mRNA fate by changing the length of its 3'UTR.
AB - Transcriptional control shapes a cell's transcriptome composition, but it is RNA processing that refines its expression. The untranslated regions (UTRs) of mRNA are hotspots for regulatory control. Features in these can impact mRNA stability, localisation and translation. Here we describe how alternative cleavage and polyadenylation can change mRNA fate by changing the length of its 3'UTR.
KW - 3'-End formation
KW - 3'UTR
KW - Alternative polyadenylation
KW - Poly(A)-tail
UR - http://www.scopus.com/inward/record.url?scp=85028835009&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2017.08.056
DO - 10.1016/j.semcdb.2017.08.056
M3 - Article
C2 - 28867199
AN - SCOPUS:85028835009
SN - 1084-9521
VL - 75
SP - 61
EP - 69
JO - Seminars in Cell & Developmental Biology
JF - Seminars in Cell & Developmental Biology
ER -