Altered sensitivity to antiviral drugs of herpes simplex virus isolates from a patient with the acquired immunodeficiency syndrome

C. J. Birch, G. Tachedjian, R. R. Doherty, K. Hayes, I. D. Gust

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Abstract

Acyclovir(ACV)-resistant herpes simplex virus type 2 (HSV–2) was isolated from apatient with acquired immunodeficiency syndrome after long-term but intermittent ACV therapy. These thymidine kinase-defective isolates were sensitive in vitro to foscamet. While combined therapy with ACV and interferon produced only partial clinical improvement, the in vitro effect of this combination against an ACV-resistant isolate from the patient was strongly synergistic. Ashort course (10–12 days) of intravenous foscamet controlled severe ulceration, and clinical improvement lasted 6 months. After recurrence and further courses of foscamet, however, the patient responded poorly, and subsequent HSV isolates were resistant to both ACV and foscamet and hypersensitive to aphidicolin.

Original languageEnglish
Pages (from-to)731-734
Number of pages4
JournalJournal of Infectious Diseases
Volume162
Issue number3
DOIs
Publication statusPublished - 1 Jan 1990
Externally publishedYes

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