Altered posterior cingulate brain metabolites and cognitive dysfunction in preterm adolescents

Jeanie L Y Cheong, Alan Bainbridge, Peter J. Anderson, Katherine J. Lee, Alice C. Burnett, Deanne K. Thompson, Gehan Roberts, Stephen J. Wood, Lex W. Doyle, Nicola J. Robertson

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Extremely preterm (EP, <28 wk gestation) individuals have increased the risk of cognitive deficits compared with controls. The posterior cingulate region has an important role in cognitive function, but how this is affected by preterm birth is unknown. We aimed to compare brain metabolite ratios of neurons and cell membranes between EP 18-y olds and controls, and explore the association between metabolite ratios and cognitive outcomes.Method:A regional cohort of 150 EP and 134 controls were recruited for the study. Cerebral metabolites were measured using proton magnetic resonance spectroscopy (MRS) obtained from a left posterior cingulate voxel. Total N-acetylaspartate (tNAA, neuronal marker)/total creatine (tCr), and total choline (tCho, cell membrane marker)/tCr ratios were compared between groups using linear regression. Metabolite ratios were correlated with tests of general intelligence (IQ), memory, and attention using linear or logistic regression.Results:Compared with controls, EP had lower tNAA/tCr (mean difference (95% CI) of-2.27% (-4.09,-0.45)) and tCho/tCr (mean difference (95% CI) of-11.11% (-20.37,-1.85)), all P = 0.02. Higher tCho/tCr correlated with better IQ in the EP group only; whereas higher tNAA/tCr ratios correlated with better scores in working memory and attention in both groups. Conclusion: EP birth is associated with long-term brain metabolite ratio alterations. This may underlie poorer cognitive performance in EP survivors.

Original languageEnglish
Pages (from-to)716-722
Number of pages7
JournalPediatric Research
Volume79
Issue number5
DOIs
Publication statusPublished - May 2016
Externally publishedYes

Cite this

Cheong, J. L. Y., Bainbridge, A., Anderson, P. J., Lee, K. J., Burnett, A. C., Thompson, D. K., ... Robertson, N. J. (2016). Altered posterior cingulate brain metabolites and cognitive dysfunction in preterm adolescents. Pediatric Research, 79(5), 716-722. https://doi.org/10.1038/pr.2015.272
Cheong, Jeanie L Y ; Bainbridge, Alan ; Anderson, Peter J. ; Lee, Katherine J. ; Burnett, Alice C. ; Thompson, Deanne K. ; Roberts, Gehan ; Wood, Stephen J. ; Doyle, Lex W. ; Robertson, Nicola J. / Altered posterior cingulate brain metabolites and cognitive dysfunction in preterm adolescents. In: Pediatric Research. 2016 ; Vol. 79, No. 5. pp. 716-722.
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abstract = "Extremely preterm (EP, <28 wk gestation) individuals have increased the risk of cognitive deficits compared with controls. The posterior cingulate region has an important role in cognitive function, but how this is affected by preterm birth is unknown. We aimed to compare brain metabolite ratios of neurons and cell membranes between EP 18-y olds and controls, and explore the association between metabolite ratios and cognitive outcomes.Method:A regional cohort of 150 EP and 134 controls were recruited for the study. Cerebral metabolites were measured using proton magnetic resonance spectroscopy (MRS) obtained from a left posterior cingulate voxel. Total N-acetylaspartate (tNAA, neuronal marker)/total creatine (tCr), and total choline (tCho, cell membrane marker)/tCr ratios were compared between groups using linear regression. Metabolite ratios were correlated with tests of general intelligence (IQ), memory, and attention using linear or logistic regression.Results:Compared with controls, EP had lower tNAA/tCr (mean difference (95{\%} CI) of-2.27{\%} (-4.09,-0.45)) and tCho/tCr (mean difference (95{\%} CI) of-11.11{\%} (-20.37,-1.85)), all P = 0.02. Higher tCho/tCr correlated with better IQ in the EP group only; whereas higher tNAA/tCr ratios correlated with better scores in working memory and attention in both groups. Conclusion: EP birth is associated with long-term brain metabolite ratio alterations. This may underlie poorer cognitive performance in EP survivors.",
author = "Cheong, {Jeanie L Y} and Alan Bainbridge and Anderson, {Peter J.} and Lee, {Katherine J.} and Burnett, {Alice C.} and Thompson, {Deanne K.} and Gehan Roberts and Wood, {Stephen J.} and Doyle, {Lex W.} and Robertson, {Nicola J.}",
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Cheong, JLY, Bainbridge, A, Anderson, PJ, Lee, KJ, Burnett, AC, Thompson, DK, Roberts, G, Wood, SJ, Doyle, LW & Robertson, NJ 2016, 'Altered posterior cingulate brain metabolites and cognitive dysfunction in preterm adolescents' Pediatric Research, vol. 79, no. 5, pp. 716-722. https://doi.org/10.1038/pr.2015.272

Altered posterior cingulate brain metabolites and cognitive dysfunction in preterm adolescents. / Cheong, Jeanie L Y; Bainbridge, Alan; Anderson, Peter J.; Lee, Katherine J.; Burnett, Alice C.; Thompson, Deanne K.; Roberts, Gehan; Wood, Stephen J.; Doyle, Lex W.; Robertson, Nicola J.

In: Pediatric Research, Vol. 79, No. 5, 05.2016, p. 716-722.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Altered posterior cingulate brain metabolites and cognitive dysfunction in preterm adolescents

AU - Cheong, Jeanie L Y

AU - Bainbridge, Alan

AU - Anderson, Peter J.

AU - Lee, Katherine J.

AU - Burnett, Alice C.

AU - Thompson, Deanne K.

AU - Roberts, Gehan

AU - Wood, Stephen J.

AU - Doyle, Lex W.

AU - Robertson, Nicola J.

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N2 - Extremely preterm (EP, <28 wk gestation) individuals have increased the risk of cognitive deficits compared with controls. The posterior cingulate region has an important role in cognitive function, but how this is affected by preterm birth is unknown. We aimed to compare brain metabolite ratios of neurons and cell membranes between EP 18-y olds and controls, and explore the association between metabolite ratios and cognitive outcomes.Method:A regional cohort of 150 EP and 134 controls were recruited for the study. Cerebral metabolites were measured using proton magnetic resonance spectroscopy (MRS) obtained from a left posterior cingulate voxel. Total N-acetylaspartate (tNAA, neuronal marker)/total creatine (tCr), and total choline (tCho, cell membrane marker)/tCr ratios were compared between groups using linear regression. Metabolite ratios were correlated with tests of general intelligence (IQ), memory, and attention using linear or logistic regression.Results:Compared with controls, EP had lower tNAA/tCr (mean difference (95% CI) of-2.27% (-4.09,-0.45)) and tCho/tCr (mean difference (95% CI) of-11.11% (-20.37,-1.85)), all P = 0.02. Higher tCho/tCr correlated with better IQ in the EP group only; whereas higher tNAA/tCr ratios correlated with better scores in working memory and attention in both groups. Conclusion: EP birth is associated with long-term brain metabolite ratio alterations. This may underlie poorer cognitive performance in EP survivors.

AB - Extremely preterm (EP, <28 wk gestation) individuals have increased the risk of cognitive deficits compared with controls. The posterior cingulate region has an important role in cognitive function, but how this is affected by preterm birth is unknown. We aimed to compare brain metabolite ratios of neurons and cell membranes between EP 18-y olds and controls, and explore the association between metabolite ratios and cognitive outcomes.Method:A regional cohort of 150 EP and 134 controls were recruited for the study. Cerebral metabolites were measured using proton magnetic resonance spectroscopy (MRS) obtained from a left posterior cingulate voxel. Total N-acetylaspartate (tNAA, neuronal marker)/total creatine (tCr), and total choline (tCho, cell membrane marker)/tCr ratios were compared between groups using linear regression. Metabolite ratios were correlated with tests of general intelligence (IQ), memory, and attention using linear or logistic regression.Results:Compared with controls, EP had lower tNAA/tCr (mean difference (95% CI) of-2.27% (-4.09,-0.45)) and tCho/tCr (mean difference (95% CI) of-11.11% (-20.37,-1.85)), all P = 0.02. Higher tCho/tCr correlated with better IQ in the EP group only; whereas higher tNAA/tCr ratios correlated with better scores in working memory and attention in both groups. Conclusion: EP birth is associated with long-term brain metabolite ratio alterations. This may underlie poorer cognitive performance in EP survivors.

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