Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming

Magdalena Plebanski, Edwin A M Lee, Carolyn M. Hannan, Katie L. Flanagan, Sarah C. Gilbert, Michael B. Gravenor, Adrian V S Hill

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Abstract

Variation in epitopes of infectious pathogens inhibits various effector functions of T lymphocytes through antagonism of the T-cell receptor. However, a more powerful strategy for immune evasion would be to prevent the induction of T-cell responses. We report here mutual 'interference' with the priming of human T-cell responses by a pair of naturally occurring variants of a malaria cytotoxic T-cell epitope. Interference with priming also occurs in vivo for a murine malaria T-cell epitope. Reshaping of the T-cell repertoire by such immune interference during naive T-cell induction may provide a general mechanism for observed patterns of immunodominance and persistence by many polymorphic pathogens.

Original languageEnglish
Pages (from-to)565-571
Number of pages7
JournalNature Medicine
Volume5
Issue number5
DOIs
Publication statusPublished - May 1999
Externally publishedYes

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