Altered lymphocyte heat shock protein 70 expression in patients with HIV disease

Linda L. Agnew; Mark Kelly; Jonathan Howard; Sarangapany Jeganathan; Marijka Batterham; Rosemary A. Ffrench; Julian Gold; Kenneth Watson

doi:10.1097/00002030-200309050-00019

Altered lymphocyte heat shock protein 70 expression in patients with HIV disease

Linda L. Agnew, Mark Kelly, Jonathan Howard, Sarangapany Jeganathan, Marijka Batterham, Rosemary A. Ffrench, Julian Gold, Kenneth Watson

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

Heat shock protein (HSP) expression in lymphocytes isolated from 20 patients with HIV disease and 15 age-matched controls was determined. Fold increases in lymphocyte hsp70 expression after heat shock were 4.52 ± 2.97 in HIV-positive individuals compared with 2.60 ± 1.29 for HIV-negative controls (P=0.001). Given clear roles for HSP in the cross-presentation of antigens, α-defensin internalization and pro-inflammatory cytokine production, a further investigation of HSP in HIV patients is merited.

Original language	English
Pages (from-to)	1985-1988
Number of pages	4
Journal	AIDS
Volume	17
Issue number	13
DOIs	https://doi.org/10.1097/00002030-200309050-00019
Publication status	Published - 5 Sept 2003
Externally published	Yes

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10.1097/00002030-200309050-00019

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abstract = "Heat shock protein (HSP) expression in lymphocytes isolated from 20 patients with HIV disease and 15 age-matched controls was determined. Fold increases in lymphocyte hsp70 expression after heat shock were 4.52 ± 2.97 in HIV-positive individuals compared with 2.60 ± 1.29 for HIV-negative controls (P=0.001). Given clear roles for HSP in the cross-presentation of antigens, α-defensin internalization and pro-inflammatory cytokine production, a further investigation of HSP in HIV patients is merited.",

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T1 - Altered lymphocyte heat shock protein 70 expression in patients with HIV disease

AU - Agnew, Linda L.

AU - Kelly, Mark

AU - Howard, Jonathan

AU - Jeganathan, Sarangapany

AU - Batterham, Marijka

AU - Ffrench, Rosemary A.

AU - Gold, Julian

AU - Watson, Kenneth

PY - 2003/9/5

Y1 - 2003/9/5

N2 - Heat shock protein (HSP) expression in lymphocytes isolated from 20 patients with HIV disease and 15 age-matched controls was determined. Fold increases in lymphocyte hsp70 expression after heat shock were 4.52 ± 2.97 in HIV-positive individuals compared with 2.60 ± 1.29 for HIV-negative controls (P=0.001). Given clear roles for HSP in the cross-presentation of antigens, α-defensin internalization and pro-inflammatory cytokine production, a further investigation of HSP in HIV patients is merited.

AB - Heat shock protein (HSP) expression in lymphocytes isolated from 20 patients with HIV disease and 15 age-matched controls was determined. Fold increases in lymphocyte hsp70 expression after heat shock were 4.52 ± 2.97 in HIV-positive individuals compared with 2.60 ± 1.29 for HIV-negative controls (P=0.001). Given clear roles for HSP in the cross-presentation of antigens, α-defensin internalization and pro-inflammatory cytokine production, a further investigation of HSP in HIV patients is merited.

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U2 - 10.1097/00002030-200309050-00019

DO - 10.1097/00002030-200309050-00019

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AN - SCOPUS:0041326857

SN - 0269-9370

VL - 17

SP - 1985

EP - 1988

JO - AIDS

JF - AIDS

IS - 13

ER -

Altered lymphocyte heat shock protein 70 expression in patients with HIV disease

Abstract

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