Altered lymphocyte heat shock protein 70 expression in patients with HIV disease

Linda L. Agnew, Mark Kelly, Jonathan Howard, Sarangapany Jeganathan, Marijka Batterham, Rosemary A. Ffrench, Julian Gold, Kenneth Watson

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15 Citations (Scopus)

Abstract

Heat shock protein (HSP) expression in lymphocytes isolated from 20 patients with HIV disease and 15 age-matched controls was determined. Fold increases in lymphocyte hsp70 expression after heat shock were 4.52 ± 2.97 in HIV-positive individuals compared with 2.60 ± 1.29 for HIV-negative controls (P=0.001). Given clear roles for HSP in the cross-presentation of antigens, α-defensin internalization and pro-inflammatory cytokine production, a further investigation of HSP in HIV patients is merited.

Original languageEnglish
Pages (from-to)1985-1988
Number of pages4
JournalAIDS
Volume17
Issue number13
DOIs
Publication statusPublished - 5 Sep 2003
Externally publishedYes

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