TY - JOUR
T1 - Altered corticostriatal functional connectivity in obsessive-compulsive disorder
AU - Harrison, B J
AU - Soriano-Mas, Carles
AU - Pujol, Jesus M
AU - Ortiz, Hector
AU - Lopez-Sola, Marina
AU - Hernandez-Ribas, Rosa
AU - Deus, Joan
AU - Alonso, Pino
AU - Yucel, Murat
AU - Pantelis, Christos
AU - Menchon, Jose Manuel
AU - Cardoner, Narcis
PY - 2009
Y1 - 2009
N2 - Neurobiological models of obsessive-compulsive disorder (OCD) emphasize disturbances in the function and connectivity of brain corticostriatal networks, or loops. Although neuroimaging studies of patients have supported this network model of OCD, very few have applied measurements that are sensitive to brain connectivity features. Objective: Using resting-state functional magnetic resonance imaging, we tested the hypothesis that OCD is associated with disturbances in the functional connectivity of primarily ventral corticostriatal regions, measured from coherent spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) signal.
AB - Neurobiological models of obsessive-compulsive disorder (OCD) emphasize disturbances in the function and connectivity of brain corticostriatal networks, or loops. Although neuroimaging studies of patients have supported this network model of OCD, very few have applied measurements that are sensitive to brain connectivity features. Objective: Using resting-state functional magnetic resonance imaging, we tested the hypothesis that OCD is associated with disturbances in the functional connectivity of primarily ventral corticostriatal regions, measured from coherent spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) signal.
UR - http://archpsyc.jamanetwork.com/article.aspx?articleid=210415
U2 - 10.1001/archgenpsychiatry.2009.152
DO - 10.1001/archgenpsychiatry.2009.152
M3 - Article
SN - 0003-990X
VL - 66
SP - 1189
EP - 1200
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 11
ER -