Altered corticostriatal functional connectivity in obsessive-compulsive disorder

B J Harrison, Carles Soriano-Mas, Jesus M Pujol, Hector Ortiz, Marina Lopez-Sola, Rosa Hernandez-Ribas, Joan Deus, Pino Alonso, Murat Yucel, Christos Pantelis, Jose Manuel Menchon, Narcis Cardoner

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Abstract

Neurobiological models of obsessive-compulsive disorder (OCD) emphasize disturbances in the function and connectivity of brain corticostriatal networks, or loops. Although neuroimaging studies of patients have supported this network model of OCD, very few have applied measurements that are sensitive to brain connectivity features. Objective: Using resting-state functional magnetic resonance imaging, we tested the hypothesis that OCD is associated with disturbances in the functional connectivity of primarily ventral corticostriatal regions, measured from coherent spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) signal.
Original languageEnglish
Pages (from-to)1189 - 1200
Number of pages12
JournalArchives of General Psychiatry
Volume66
Issue number11
DOIs
Publication statusPublished - 2009
Externally publishedYes

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