Projects per year
Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.
|Number of pages||5|
|Journal||Annals of Clinical and Translational Neurology|
|Publication status||Published - 1 Jul 2014|
- 2 Finished
Cognitive, behavioural and educational outcomes of fetal antiepileptic drug exposure
Wood, A., Hartmann, P. L., Reutens, D., Vajda, F. & Anderson, V.
Australian Research Council (ARC), Royal Melbourne Hospital
14/09/06 → 31/12/11