Altered brain response to verbal learning following sleep deprivation

Sean P.A. Drummond, Gregory G. Brown, J. Christian Gillin, John L. Stricker, Eric C. Wong, Richard B. Buxton

Research output: Contribution to journalArticleResearchpeer-review

420 Citations (Scopus)

Abstract

The effects of sleep deprivation on the neural substrates of cognition are poorly understood. Here we used functional magnetic resonance imaging to measure the effects of 35 hours of sleep deprivation on cerebral activation during verbal learning in normal young volunteers. On the basis of a previous hypothesis, we predicted that the prefrontal cortex (PFC) would be less responsive to cognitive demands following sleep deprivation. Contrary to our expectations, however, the PFC was more responsive after one night of sleep deprivation than after normal sleep. Increased subjective sleepiness in sleep-deprived subject correlated significantly with activation of the PFC. The temporal lobe was activated after normal sleep but not after sleep deprivation; in contrast, the parietal lobes were not activated after normal sleep but were activated after sleep deprivation. Although sleep deprivation significantly impaired free recall compared with the rested state, better free recall in sleep-deprived subjects was associated with greater parietal lobe activation. These findings show that there are dynamic, compensatory changes in cerebral activation during verbal learning after sleep deprivation and implicate the PFC and parietal lobes in this compensation.

Original languageEnglish
Pages (from-to)655-657
Number of pages3
JournalNature
Volume403
Issue number6770
DOIs
Publication statusPublished - 10 Feb 2000
Externally publishedYes

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