Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

Lotta E. Oikari, Rucha Pandit, Romal Stewart, Carla Cuní-López, Hazel Quek, Ratneswary Sutharsan, Laura M. Rantanen, Minna Oksanen, Sarka Lehtonen, Carmela Maria de Boer, Jose M. Polo, Jürgen Götz, Jari Koistinaho, Anthony R. White

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Abstract

In this article, Oikari and colleagues use patient-derived iPSCs with a familial Alzheimer disease (AD) mutation to study the phenotypical and functional differences of brain endothelial cells (iBECs) in AD. In addition, the authors study the effects of focused ultrasound on the iBEC monolayer to model blood-brain barrier opening and demonstrate key differences between AD and control iBECs.

Original languageEnglish
Pages (from-to)924-939
Number of pages16
JournalStem Cell Reports
Volume14
Issue number5
DOIs
Publication statusPublished - 12 May 2020

Keywords

  • Alzheimer disease
  • blood-brain barrier
  • endothelial cells
  • focused ultrasound
  • induced brain endothelial cells
  • induced pluripotent stem cells
  • tight junctions
  • ultrasound therapy

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