Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

Lotta E. Oikari; Rucha Pandit; Romal Stewart; Carla Cuní-López; Hazel Quek; Ratneswary Sutharsan; Laura M. Rantanen; Minna Oksanen; Sarka Lehtonen; Carmela Maria de Boer; Jose M. Polo; Jürgen Götz; Jari Koistinaho; Anthony R. White

doi:10.1016/j.stemcr.2020.03.011

Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

Lotta E. Oikari, Rucha Pandit, Romal Stewart, Carla Cuní-López, Hazel Quek, Ratneswary Sutharsan, Laura M. Rantanen, Minna Oksanen, Sarka Lehtonen, Carmela Maria de Boer, Jose M. Polo, Jürgen Götz, Jari Koistinaho, Anthony R. White

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

In this article, Oikari and colleagues use patient-derived iPSCs with a familial Alzheimer disease (AD) mutation to study the phenotypical and functional differences of brain endothelial cells (iBECs) in AD. In addition, the authors study the effects of focused ultrasound on the iBEC monolayer to model blood-brain barrier opening and demonstrate key differences between AD and control iBECs.

Original language	English
Pages (from-to)	924-939
Number of pages	16
Journal	Stem Cell Reports
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/j.stemcr.2020.03.011
Publication status	Published - 12 May 2020

Keywords

Alzheimer disease
blood-brain barrier
endothelial cells
focused ultrasound
induced brain endothelial cells
induced pluripotent stem cells
tight junctions
ultrasound therapy

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10.1016/j.stemcr.2020.03.011

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Oikari, L. E., Pandit, R., Stewart, R., Cuní-López, C., Quek, H., Sutharsan, R., Rantanen, L. M., Oksanen, M., Lehtonen, S., de Boer, C. M., Polo, J. M., Götz, J., Koistinaho, J., & White, A. R. (2020). Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery. Stem Cell Reports, 14(5), 924-939. https://doi.org/10.1016/j.stemcr.2020.03.011

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title = "Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery",

abstract = "In this article, Oikari and colleagues use patient-derived iPSCs with a familial Alzheimer disease (AD) mutation to study the phenotypical and functional differences of brain endothelial cells (iBECs) in AD. In addition, the authors study the effects of focused ultrasound on the iBEC monolayer to model blood-brain barrier opening and demonstrate key differences between AD and control iBECs.",

keywords = "Alzheimer disease, blood-brain barrier, endothelial cells, focused ultrasound, induced brain endothelial cells, induced pluripotent stem cells, tight junctions, ultrasound therapy",

author = "Oikari, {Lotta E.} and Rucha Pandit and Romal Stewart and Carla Cun{\'i}-L{\'o}pez and Hazel Quek and Ratneswary Sutharsan and Rantanen, {Laura M.} and Minna Oksanen and Sarka Lehtonen and {de Boer}, {Carmela Maria} and Polo, {Jose M.} and J{\"u}rgen G{\"o}tz and Jari Koistinaho and White, {Anthony R.}",

year = "2020",

month = may,

day = "12",

doi = "10.1016/j.stemcr.2020.03.011",

language = "English",

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Oikari, LE, Pandit, R, Stewart, R, Cuní-López, C, Quek, H, Sutharsan, R, Rantanen, LM, Oksanen, M, Lehtonen, S, de Boer, CM, Polo, JM, Götz, J, Koistinaho, J & White, AR 2020, 'Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery', Stem Cell Reports, vol. 14, no. 5, pp. 924-939. https://doi.org/10.1016/j.stemcr.2020.03.011

TY - JOUR

T1 - Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

AU - Oikari, Lotta E.

AU - Pandit, Rucha

AU - Stewart, Romal

AU - Cuní-López, Carla

AU - Quek, Hazel

AU - Sutharsan, Ratneswary

AU - Rantanen, Laura M.

AU - Oksanen, Minna

AU - Lehtonen, Sarka

AU - de Boer, Carmela Maria

AU - Polo, Jose M.

AU - Götz, Jürgen

AU - Koistinaho, Jari

AU - White, Anthony R.

PY - 2020/5/12

Y1 - 2020/5/12

N2 - In this article, Oikari and colleagues use patient-derived iPSCs with a familial Alzheimer disease (AD) mutation to study the phenotypical and functional differences of brain endothelial cells (iBECs) in AD. In addition, the authors study the effects of focused ultrasound on the iBEC monolayer to model blood-brain barrier opening and demonstrate key differences between AD and control iBECs.

AB - In this article, Oikari and colleagues use patient-derived iPSCs with a familial Alzheimer disease (AD) mutation to study the phenotypical and functional differences of brain endothelial cells (iBECs) in AD. In addition, the authors study the effects of focused ultrasound on the iBEC monolayer to model blood-brain barrier opening and demonstrate key differences between AD and control iBECs.

KW - Alzheimer disease

KW - blood-brain barrier

KW - endothelial cells

KW - focused ultrasound

KW - induced brain endothelial cells

KW - induced pluripotent stem cells

KW - tight junctions

KW - ultrasound therapy

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U2 - 10.1016/j.stemcr.2020.03.011

DO - 10.1016/j.stemcr.2020.03.011

M3 - Article

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AN - SCOPUS:85084694191

VL - 14

SP - 924

EP - 939

JO - Stem Cell Reports

JF - Stem Cell Reports

SN - 2213-6711

IS - 5

ER -

Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

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