Alterations in the optic radiations of very preterm children - Perinatal predictors and relationships with visual outcomes

Deanne K. Thompson, Dolly Thai, Claire E. Kelly, Alexander Leemans, Jacques Donald Tournier, Michael J. Kean, Katherine J. Lee, Terrie E. Inder, Lex W. Doyle, Peter J. Anderson, Rodney W. Hunt

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Children born very preterm (VPT) are at risk for visual impairments, the main risk factors being retinopathy of prematurity and cerebral white matter injury, however these only partially account for visual impairments in VPT children. This study aimed to compare optic radiation microstructure and volume between VPT and term-born children, and to investigate associations between 1) perinatal variables and optic radiations; 2) optic radiations and visual function in VPT children. We hypothesized that optic radiation microstructure would be altered in VPT children, predicted by neonatal cerebral white matter abnormality and retinopathy of prematurity, and associated with visual impairments. 142 VPT children and 32 controls underwent diffusion-weighted magnetic resonance imaging at 7 years of age. Optic radiations were delineated using constrained spherical deconvolution tractography. Tract volume and average diffusion tensor values for the whole optic radiations and three sub-regions were compared between the VPT and control groups, and correlated with perinatal variables and 7-year visual outcome data. Total tract volumes and average diffusion values were similar between VPT and control groups. On regional analysis of the optic radiation, mean and radial diffusivity were higher within the middle sub-regions in VPT compared with control children. Neonatal white matter abnormalities and retinopathy of prematurity were associated with optic radiation diffusion values. Lower fractional anisotropy in the anterior sub-regions was associated with poor visual acuity and increased likelihood of other visual defects. This study presents evidence for microstructural alterations in the optic radiations of VPT children, which are largely predicted by white matter abnormality or severe retinopathy of prematurity, and may partially explain the higher rate of visual impairments in VPT children. 

Original languageEnglish
Pages (from-to)145-153
Number of pages9
JournalNeuroImage: Clinical
Volume4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Diffusion weighted imaging
  • Magnetic resonance imaging
  • Prematurity
  • Tractography
  • Visual system

Cite this

Thompson, D. K., Thai, D., Kelly, C. E., Leemans, A., Tournier, J. D., Kean, M. J., ... Hunt, R. W. (2014). Alterations in the optic radiations of very preterm children - Perinatal predictors and relationships with visual outcomes. NeuroImage: Clinical, 4, 145-153. https://doi.org/10.1016/j.nicl.2013.11.007
Thompson, Deanne K. ; Thai, Dolly ; Kelly, Claire E. ; Leemans, Alexander ; Tournier, Jacques Donald ; Kean, Michael J. ; Lee, Katherine J. ; Inder, Terrie E. ; Doyle, Lex W. ; Anderson, Peter J. ; Hunt, Rodney W. / Alterations in the optic radiations of very preterm children - Perinatal predictors and relationships with visual outcomes. In: NeuroImage: Clinical. 2014 ; Vol. 4. pp. 145-153.
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abstract = "Children born very preterm (VPT) are at risk for visual impairments, the main risk factors being retinopathy of prematurity and cerebral white matter injury, however these only partially account for visual impairments in VPT children. This study aimed to compare optic radiation microstructure and volume between VPT and term-born children, and to investigate associations between 1) perinatal variables and optic radiations; 2) optic radiations and visual function in VPT children. We hypothesized that optic radiation microstructure would be altered in VPT children, predicted by neonatal cerebral white matter abnormality and retinopathy of prematurity, and associated with visual impairments. 142 VPT children and 32 controls underwent diffusion-weighted magnetic resonance imaging at 7 years of age. Optic radiations were delineated using constrained spherical deconvolution tractography. Tract volume and average diffusion tensor values for the whole optic radiations and three sub-regions were compared between the VPT and control groups, and correlated with perinatal variables and 7-year visual outcome data. Total tract volumes and average diffusion values were similar between VPT and control groups. On regional analysis of the optic radiation, mean and radial diffusivity were higher within the middle sub-regions in VPT compared with control children. Neonatal white matter abnormalities and retinopathy of prematurity were associated with optic radiation diffusion values. Lower fractional anisotropy in the anterior sub-regions was associated with poor visual acuity and increased likelihood of other visual defects. This study presents evidence for microstructural alterations in the optic radiations of VPT children, which are largely predicted by white matter abnormality or severe retinopathy of prematurity, and may partially explain the higher rate of visual impairments in VPT children. ",
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Thompson, DK, Thai, D, Kelly, CE, Leemans, A, Tournier, JD, Kean, MJ, Lee, KJ, Inder, TE, Doyle, LW, Anderson, PJ & Hunt, RW 2014, 'Alterations in the optic radiations of very preterm children - Perinatal predictors and relationships with visual outcomes' NeuroImage: Clinical, vol. 4, pp. 145-153. https://doi.org/10.1016/j.nicl.2013.11.007

Alterations in the optic radiations of very preterm children - Perinatal predictors and relationships with visual outcomes. / Thompson, Deanne K.; Thai, Dolly; Kelly, Claire E.; Leemans, Alexander; Tournier, Jacques Donald; Kean, Michael J.; Lee, Katherine J.; Inder, Terrie E.; Doyle, Lex W.; Anderson, Peter J.; Hunt, Rodney W.

In: NeuroImage: Clinical, Vol. 4, 2014, p. 145-153.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Alterations in the optic radiations of very preterm children - Perinatal predictors and relationships with visual outcomes

AU - Thompson, Deanne K.

AU - Thai, Dolly

AU - Kelly, Claire E.

AU - Leemans, Alexander

AU - Tournier, Jacques Donald

AU - Kean, Michael J.

AU - Lee, Katherine J.

AU - Inder, Terrie E.

AU - Doyle, Lex W.

AU - Anderson, Peter J.

AU - Hunt, Rodney W.

PY - 2014

Y1 - 2014

N2 - Children born very preterm (VPT) are at risk for visual impairments, the main risk factors being retinopathy of prematurity and cerebral white matter injury, however these only partially account for visual impairments in VPT children. This study aimed to compare optic radiation microstructure and volume between VPT and term-born children, and to investigate associations between 1) perinatal variables and optic radiations; 2) optic radiations and visual function in VPT children. We hypothesized that optic radiation microstructure would be altered in VPT children, predicted by neonatal cerebral white matter abnormality and retinopathy of prematurity, and associated with visual impairments. 142 VPT children and 32 controls underwent diffusion-weighted magnetic resonance imaging at 7 years of age. Optic radiations were delineated using constrained spherical deconvolution tractography. Tract volume and average diffusion tensor values for the whole optic radiations and three sub-regions were compared between the VPT and control groups, and correlated with perinatal variables and 7-year visual outcome data. Total tract volumes and average diffusion values were similar between VPT and control groups. On regional analysis of the optic radiation, mean and radial diffusivity were higher within the middle sub-regions in VPT compared with control children. Neonatal white matter abnormalities and retinopathy of prematurity were associated with optic radiation diffusion values. Lower fractional anisotropy in the anterior sub-regions was associated with poor visual acuity and increased likelihood of other visual defects. This study presents evidence for microstructural alterations in the optic radiations of VPT children, which are largely predicted by white matter abnormality or severe retinopathy of prematurity, and may partially explain the higher rate of visual impairments in VPT children. 

AB - Children born very preterm (VPT) are at risk for visual impairments, the main risk factors being retinopathy of prematurity and cerebral white matter injury, however these only partially account for visual impairments in VPT children. This study aimed to compare optic radiation microstructure and volume between VPT and term-born children, and to investigate associations between 1) perinatal variables and optic radiations; 2) optic radiations and visual function in VPT children. We hypothesized that optic radiation microstructure would be altered in VPT children, predicted by neonatal cerebral white matter abnormality and retinopathy of prematurity, and associated with visual impairments. 142 VPT children and 32 controls underwent diffusion-weighted magnetic resonance imaging at 7 years of age. Optic radiations were delineated using constrained spherical deconvolution tractography. Tract volume and average diffusion tensor values for the whole optic radiations and three sub-regions were compared between the VPT and control groups, and correlated with perinatal variables and 7-year visual outcome data. Total tract volumes and average diffusion values were similar between VPT and control groups. On regional analysis of the optic radiation, mean and radial diffusivity were higher within the middle sub-regions in VPT compared with control children. Neonatal white matter abnormalities and retinopathy of prematurity were associated with optic radiation diffusion values. Lower fractional anisotropy in the anterior sub-regions was associated with poor visual acuity and increased likelihood of other visual defects. This study presents evidence for microstructural alterations in the optic radiations of VPT children, which are largely predicted by white matter abnormality or severe retinopathy of prematurity, and may partially explain the higher rate of visual impairments in VPT children. 

KW - Diffusion weighted imaging

KW - Magnetic resonance imaging

KW - Prematurity

KW - Tractography

KW - Visual system

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JF - NeuroImage: Clinical

SN - 2213-1582

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