Alterations in Peripheral Blood B Cell Subsets and Dynamics of B Cell Responses during Human Schistosomiasis

Lucja A. Labuda, Ulysse Ateba-Ngoa, Eliane Ngoune Feugap, Jorn J. Heeringa, Luciën E P M van der Vlugt, Regina B A Pires, Ludovic Mewono, Peter G. Kremsner, Menno C. van Zelm, Ayola A. Adegnika, Maria Yazdanbakhsh, Hermelijn H. Smits

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Abstract

Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulation in Gabonese schoolchildren with Schistosoma haematobium infection. Frequencies of memory B cell (MBC) subsets were increased, whereas naive B cell frequencies were reduced in the schistosome-infected group. At the functional level, isolated B cells from schistosome-infected children showed higher expression of the activation marker CD23 upon stimulation, but lower proliferation and TNF-α production. Importantly, 6-months after 3 rounds of praziquantel treatment, frequencies of naive B cells were increased, MBC frequencies were decreased and with the exception of TNF-α production, B cell responsiveness was restored to what was seen in uninfected children. These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level.

Original languageEnglish
Article numbere2094
JournalPLoS Neglected Tropical Diseases
Volume7
Issue number3
DOIs
Publication statusPublished - 2013
Externally publishedYes

Cite this

Labuda, L. A., Ateba-Ngoa, U., Feugap, E. N., Heeringa, J. J., van der Vlugt, L. E. P. M., Pires, R. B. A., Mewono, L., Kremsner, P. G., van Zelm, M. C., Adegnika, A. A., Yazdanbakhsh, M., & Smits, H. H. (2013). Alterations in Peripheral Blood B Cell Subsets and Dynamics of B Cell Responses during Human Schistosomiasis. PLoS Neglected Tropical Diseases, 7(3), [e2094]. https://doi.org/10.1371/journal.pntd.0002094