Alterations in peptidoglycan of Neisseria gonorrhoeae induced by sub-MICs of β-lactam antibiotics

J. F. Garcia-Bustos, T. J. Dougherty

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Abstract

Exposure of Neisseria gonorrhoeae to sub-MICs of selected β-lactam antibiotics caused distortion of normal cell morphology. Analysis of the peptidoglycan indicated that the cells were accumulating increased quantities of disaccharide pentapeptide in their cell walls. The O-acetylated form of the disaccharide pentapeptide was not detected among the major peaks. The correlation of antibiotic binding to gonococcal penicillin-binding protein 2 and accumulation of non-O-acetylated disaccharide pentapeptide suggested an explanation for the previously observed relationship of penicillin-binding protein 2 and O-acetylation of peptidoglycan.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume31
Issue number2
DOIs
Publication statusPublished - 1 Jan 1987
Externally publishedYes

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