Alterations in pain processing circuitries in episodic migraine

Tiffani J. Mungoven, Kasia K. Marciszewski, Vaughan G. Macefield, Paul M. Macey, Luke A. Henderson, Noemi Meylakh

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)


Background: The precise underlying mechanisms of migraine remain unknown. Although we have previously shown acute orofacial pain evoked changes within the brainstem of individuals with migraine, we do not know if these brainstem alterations are driven by changes in higher cortical regions. The aim of this investigation is to extend our previous investigation to determine if higher brain centers display altered activation patterns and connectivity in migraineurs during acute orofacial noxious stimuli. Methods: Functional magnetic resonance imaging was performed in 29 healthy controls and 25 migraineurs during the interictal and immediately (within 24-h) prior to migraine phases. We assessed activation of higher cortical areas during noxious orofacial heat stimulation using a thermode device and assessed whole scan and pain-related changes in connectivity. Results: Despite similar overall pain intensity ratings between all three groups, migraineurs in the group immediately prior to migraine displayed greater activation of the ipsilateral nucleus accumbens, the contralateral ventrolateral prefrontal cortex and two clusters in the dorsolateral prefrontal cortex (dlPFC). Reduced whole scan dlPFC [Z + 44] connectivity with cortical/subcortical and brainstem regions involved in pain modulation such as the putamen and primary motor cortex was demonstrated in migraineurs. Pain-related changes in connectivity of the dlPFC and the hypothalamus immediately prior to migraine was also found to be reduced with brainstem pain modulatory areas such as the rostral ventromedial medulla and dorsolateral pons. Conclusions: These data reveal that the modulation of brainstem pain modulatory areas by higher cortical regions may be aberrant during pain and these alterations in this descending pain modulatory pathway manifests exclusively prior to the development of a migraine attack.

Original languageEnglish
Article number9
Number of pages15
JournalThe Journal of Headache and Pain
Issue number1
Publication statusPublished - 15 Jan 2022
Externally publishedYes


  • Brainstem pain modulation
  • Cortical pain modulation
  • Dorsolateral prefrontal cortex
  • Functional connectivity
  • Hypothalamus
  • Migraine
  • Orofacial pain
  • PPI
  • Spinal trigeminal nucleus

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