TY - JOUR
T1 - Alteration to hippocampal shape in cannabis users with and without schizophrenia
AU - Solowij, Nadia
AU - Walterfang, Mark
AU - Lubman, Dan
AU - Whittle, Sarah
AU - Lorenzetti, Valentina
AU - Styner, Martin
AU - Velakoulis, Dennis
AU - Pantelis, Christos
AU - Yucel, Murat
PY - 2013
Y1 - 2013
N2 - Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users. There is a paucity of research investigating potential additive effects of cannabis use on brain pathology associated with schizophrenia. In this study, we performed hippocampal shape analysis in cannabis-using and non-using patients with schizophrenia, healthy cannabis users and healthy non-using controls. Hippocampal shape changes were observed in each group relative to controls, with the greatest degree of alterations (i.e., deflations across the hippocampus, and with an anterior predisposition), in cannabis-using schizophrenia patients. These alterations were associated with cannabis use patterns and psychotic symptoms.
AB - Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users. There is a paucity of research investigating potential additive effects of cannabis use on brain pathology associated with schizophrenia. In this study, we performed hippocampal shape analysis in cannabis-using and non-using patients with schizophrenia, healthy cannabis users and healthy non-using controls. Hippocampal shape changes were observed in each group relative to controls, with the greatest degree of alterations (i.e., deflations across the hippocampus, and with an anterior predisposition), in cannabis-using schizophrenia patients. These alterations were associated with cannabis use patterns and psychotic symptoms.
UR - http://linkinghub.elsevier.com/retrieve/pii/S0920-9964(12)00614-7
U2 - 10.1016/j.schres.2012.10.040
DO - 10.1016/j.schres.2012.10.040
M3 - Article
VL - 143
SP - 179
EP - 184
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1
ER -