Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells

Ebru Boslem; Jacquelyn M. Weir; Gemma MacIntosh; Nancy Sue; James Cantley; Peter J. Meikle; Trevor J. Biden

doi:10.1074/jbc.M113.489310

Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells

Ebru Boslem, Jacquelyn M. Weir, Gemma MacIntosh, Nancy Sue, James Cantley, Peter J. Meikle, Trevor J. Biden

Research output: Contribution to journal › Article › Research › peer-review

109 Citations (Scopus)

Abstract

Background: Saturated fatty acids disrupt protein trafficking and promote endoplasmic reticulum (ER) stress in pancreatic β-cells. Results: Chronic palmitate selectively reduces ER sphingomyelin and cholesterol and disrupts ER lipid rafts. Conclusion: Altered ER lipid rafts contribute to defective ER protein export. Significance: This provides novel insights into the mechanisms of β-cell death that underlie type 2 diabetes.

Original language	English
Pages (from-to)	26569-26582
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	288
Issue number	37
DOIs	https://doi.org/10.1074/jbc.M113.489310
Publication status	Published - 13 Sept 2013
Externally published	Yes

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10.1074/jbc.M113.489310

Cite this

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abstract = "Background: Saturated fatty acids disrupt protein trafficking and promote endoplasmic reticulum (ER) stress in pancreatic β-cells. Results: Chronic palmitate selectively reduces ER sphingomyelin and cholesterol and disrupts ER lipid rafts. Conclusion: Altered ER lipid rafts contribute to defective ER protein export. Significance: This provides novel insights into the mechanisms of β-cell death that underlie type 2 diabetes.",

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AU - Boslem, Ebru

AU - Weir, Jacquelyn M.

AU - MacIntosh, Gemma

AU - Sue, Nancy

AU - Cantley, James

AU - Meikle, Peter J.

AU - Biden, Trevor J.

PY - 2013/9/13

Y1 - 2013/9/13

N2 - Background: Saturated fatty acids disrupt protein trafficking and promote endoplasmic reticulum (ER) stress in pancreatic β-cells. Results: Chronic palmitate selectively reduces ER sphingomyelin and cholesterol and disrupts ER lipid rafts. Conclusion: Altered ER lipid rafts contribute to defective ER protein export. Significance: This provides novel insights into the mechanisms of β-cell death that underlie type 2 diabetes.

AB - Background: Saturated fatty acids disrupt protein trafficking and promote endoplasmic reticulum (ER) stress in pancreatic β-cells. Results: Chronic palmitate selectively reduces ER sphingomyelin and cholesterol and disrupts ER lipid rafts. Conclusion: Altered ER lipid rafts contribute to defective ER protein export. Significance: This provides novel insights into the mechanisms of β-cell death that underlie type 2 diabetes.

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Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells

Abstract

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