Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells

Ebru Boslem, Jacquelyn M. Weir, Gemma MacIntosh, Nancy Sue, James Cantley, Peter J. Meikle, Trevor J. Biden

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

Abstract

Background: Saturated fatty acids disrupt protein trafficking and promote endoplasmic reticulum (ER) stress in pancreatic β-cells. Results: Chronic palmitate selectively reduces ER sphingomyelin and cholesterol and disrupts ER lipid rafts. Conclusion: Altered ER lipid rafts contribute to defective ER protein export. Significance: This provides novel insights into the mechanisms of β-cell death that underlie type 2 diabetes.

Original languageEnglish
Pages (from-to)26569-26582
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number37
DOIs
Publication statusPublished - 13 Sep 2013
Externally publishedYes

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