TY - JOUR
T1 - Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking
AU - Yeatman, Holly Rosena
AU - Lane, Jonathan Robert David
AU - Choy, Kwok Ho Christopher
AU - Lambert, Nevin
AU - Sexton, Patrick
AU - Christopoulos, Arthur
AU - Canals, Meritxell
PY - 2014
Y1 - 2014
N2 - Background: The effects of allosteric modulators on G protein-coupled receptor trafficking are largely unknown. Results: The allosteric ligand BQCA modulates M1 mAChR arrestin recruitment and receptor trafficking. Conclusion: M1 mAChR trafficking is arrestin- and G protein-dependent and modulated by BQCA. Significance: The impact of allosteric modulators on receptor trafficking needs to be assessed when considering this family of ligands as potential chronic therapies. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
AB - Background: The effects of allosteric modulators on G protein-coupled receptor trafficking are largely unknown. Results: The allosteric ligand BQCA modulates M1 mAChR arrestin recruitment and receptor trafficking. Conclusion: M1 mAChR trafficking is arrestin- and G protein-dependent and modulated by BQCA. Significance: The impact of allosteric modulators on receptor trafficking needs to be assessed when considering this family of ligands as potential chronic therapies. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
UR - http://www.jbc.org/content/289/22/15856.full.pdf+html
U2 - 10.1074/jbc.M113.536672
DO - 10.1074/jbc.M113.536672
M3 - Article
SN - 0021-9258
VL - 289
SP - 15856
EP - 15866
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 22
ER -