Alloreactivity

Sidonia B G Eckle; Jamie Rossjohn; James McCluskey

doi:10.1007/978-1-62703-493-7

Alloreactivity

Sidonia B G Eckle, Jamie Rossjohn, James McCluskey

Biochemistry & Molecular Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

3 Citations (Scopus)

Abstract

The alloimmune response between individuals genetically disparate for antigens encoded within the major histocompatibility complex (MHC) remains a substantial barrier to transplantation of solid organs, tissues, and hematopoietic stem cells. Alloreactivity has been an immunological paradox because of its apparent contradiction to the requirement of MHC restriction for the induction of normal T lymphocyte mediated immune responses. Through crystallographic analyses and experimental systems utilizing murine CD8(+) cytolytic T cell clones, major advances have been achieved in understanding the molecular and structural basis of T cell receptor recognition of MHC-peptide complexes and the basis of T cell mediated alloreactivity. These studies have further provided an explanation for the relatively high frequencies of alloreactive T cells compared to the frequencies of T cells for microbial derived antigens.

Original language	English
Title of host publication	Transplantation Immunology: Methods and Protocols
Editors	Andrea A Zachary, Mary S Leffell
Place of Publication	New York NY USA
Publisher	Humana Press
Pages	3 - 39
Number of pages	37
Edition	2nd
ISBN (Print)	9781627034920
DOIs	https://doi.org/10.1007/978-1-62703-493-7
Publication status	Published - 2013

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10.1007/978-1-62703-493-7

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title = "Alloreactivity",

abstract = "The alloimmune response between individuals genetically disparate for antigens encoded within the major histocompatibility complex (MHC) remains a substantial barrier to transplantation of solid organs, tissues, and hematopoietic stem cells. Alloreactivity has been an immunological paradox because of its apparent contradiction to the requirement of MHC restriction for the induction of normal T lymphocyte mediated immune responses. Through crystallographic analyses and experimental systems utilizing murine CD8(+) cytolytic T cell clones, major advances have been achieved in understanding the molecular and structural basis of T cell receptor recognition of MHC-peptide complexes and the basis of T cell mediated alloreactivity. These studies have further provided an explanation for the relatively high frequencies of alloreactive T cells compared to the frequencies of T cells for microbial derived antigens.",

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T1 - Alloreactivity

AU - Eckle, Sidonia B G

AU - Rossjohn, Jamie

AU - McCluskey, James

PY - 2013

Y1 - 2013

N2 - The alloimmune response between individuals genetically disparate for antigens encoded within the major histocompatibility complex (MHC) remains a substantial barrier to transplantation of solid organs, tissues, and hematopoietic stem cells. Alloreactivity has been an immunological paradox because of its apparent contradiction to the requirement of MHC restriction for the induction of normal T lymphocyte mediated immune responses. Through crystallographic analyses and experimental systems utilizing murine CD8(+) cytolytic T cell clones, major advances have been achieved in understanding the molecular and structural basis of T cell receptor recognition of MHC-peptide complexes and the basis of T cell mediated alloreactivity. These studies have further provided an explanation for the relatively high frequencies of alloreactive T cells compared to the frequencies of T cells for microbial derived antigens.

AB - The alloimmune response between individuals genetically disparate for antigens encoded within the major histocompatibility complex (MHC) remains a substantial barrier to transplantation of solid organs, tissues, and hematopoietic stem cells. Alloreactivity has been an immunological paradox because of its apparent contradiction to the requirement of MHC restriction for the induction of normal T lymphocyte mediated immune responses. Through crystallographic analyses and experimental systems utilizing murine CD8(+) cytolytic T cell clones, major advances have been achieved in understanding the molecular and structural basis of T cell receptor recognition of MHC-peptide complexes and the basis of T cell mediated alloreactivity. These studies have further provided an explanation for the relatively high frequencies of alloreactive T cells compared to the frequencies of T cells for microbial derived antigens.

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U2 - 10.1007/978-1-62703-493-7

DO - 10.1007/978-1-62703-493-7

M3 - Chapter (Book)

SN - 9781627034920

SP - 3

EP - 39

BT - Transplantation Immunology: Methods and Protocols

A2 - Zachary, Andrea A

A2 - Leffell, Mary S

PB - Humana Press

CY - New York NY USA

ER -

Alloreactivity

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