Alloreactivity

Sidonia B G Eckle, Jamie Rossjohn, James McCluskey

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2 Citations (Scopus)

Abstract

The alloimmune response between individuals genetically disparate for antigens encoded within the major histocompatibility complex (MHC) remains a substantial barrier to transplantation of solid organs, tissues, and hematopoietic stem cells. Alloreactivity has been an immunological paradox because of its apparent contradiction to the requirement of MHC restriction for the induction of normal T lymphocyte mediated immune responses. Through crystallographic analyses and experimental systems utilizing murine CD8(+) cytolytic T cell clones, major advances have been achieved in understanding the molecular and structural basis of T cell receptor recognition of MHC-peptide complexes and the basis of T cell mediated alloreactivity. These studies have further provided an explanation for the relatively high frequencies of alloreactive T cells compared to the frequencies of T cells for microbial derived antigens.
Original languageEnglish
Title of host publicationTransplantation Immunology: Methods and Protocols
EditorsAndrea A Zachary, Mary S Leffell
Place of PublicationNew York NY USA
PublisherHumana Press
Pages3 - 39
Number of pages37
Edition2nd
ISBN (Print)9781627034920
DOIs
Publication statusPublished - 2013

Cite this