Alloreactive natural killer cells in hematopoietic stem cell transplantation

Hollie J. Pegram; David S. Ritchie; Mark J. Smyth; Andres Wiernik; H. Miles Prince; Phillip K. Darcy; Michael H. Kershaw

doi:10.1016/j.leukres.2010.07.030

Alloreactive natural killer cells in hematopoietic stem cell transplantation

Hollie J. Pegram, David S. Ritchie, Mark J. Smyth, Andres Wiernik, H. Miles Prince, Phillip K. Darcy, Michael H. Kershaw

Immunology Alfred Hospital

Research output: Contribution to journal › Review Article › Research › peer-review

13 Citations (Scopus)

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) for leukemia can play a major role in reducing the risk of relapse by inducing a graft versus leukemia (GVL) effect. Here, we review the effectiveness of mismatching inhibitory killer-cell-immunoglobulin-like receptors (KIR) on donor natural killer (NK) cells as a mechanism for GVL. We review the range of KIR and the importance of T cell and NK cell content of the graft, together with considerations of the graft source. Further understanding of conditioning and mechanisms to reduce graft versus host disease (GVHD) will improve our ability to manipulate NK cells in HSCT.

Original language	English
Pages (from-to)	14-21
Number of pages	8
Journal	Leukemia Research
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2010.07.030
Publication status	Published - Jan 2011

Keywords

Acute myeloid leukemia
Allogeneic stem cell transplantation
Graft versus host disease
Graft versus leukemia
Immunotherapy
KIR

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2010.07.030

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title = "Alloreactive natural killer cells in hematopoietic stem cell transplantation",

abstract = "Allogeneic hematopoietic stem cell transplantation (HSCT) for leukemia can play a major role in reducing the risk of relapse by inducing a graft versus leukemia (GVL) effect. Here, we review the effectiveness of mismatching inhibitory killer-cell-immunoglobulin-like receptors (KIR) on donor natural killer (NK) cells as a mechanism for GVL. We review the range of KIR and the importance of T cell and NK cell content of the graft, together with considerations of the graft source. Further understanding of conditioning and mechanisms to reduce graft versus host disease (GVHD) will improve our ability to manipulate NK cells in HSCT.",

keywords = "Acute myeloid leukemia, Allogeneic stem cell transplantation, Graft versus host disease, Graft versus leukemia, Immunotherapy, KIR",

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AU - Pegram, Hollie J.

AU - Ritchie, David S.

AU - Smyth, Mark J.

AU - Wiernik, Andres

AU - Prince, H. Miles

AU - Darcy, Phillip K.

AU - Kershaw, Michael H.

PY - 2011/1

Y1 - 2011/1

N2 - Allogeneic hematopoietic stem cell transplantation (HSCT) for leukemia can play a major role in reducing the risk of relapse by inducing a graft versus leukemia (GVL) effect. Here, we review the effectiveness of mismatching inhibitory killer-cell-immunoglobulin-like receptors (KIR) on donor natural killer (NK) cells as a mechanism for GVL. We review the range of KIR and the importance of T cell and NK cell content of the graft, together with considerations of the graft source. Further understanding of conditioning and mechanisms to reduce graft versus host disease (GVHD) will improve our ability to manipulate NK cells in HSCT.

AB - Allogeneic hematopoietic stem cell transplantation (HSCT) for leukemia can play a major role in reducing the risk of relapse by inducing a graft versus leukemia (GVL) effect. Here, we review the effectiveness of mismatching inhibitory killer-cell-immunoglobulin-like receptors (KIR) on donor natural killer (NK) cells as a mechanism for GVL. We review the range of KIR and the importance of T cell and NK cell content of the graft, together with considerations of the graft source. Further understanding of conditioning and mechanisms to reduce graft versus host disease (GVHD) will improve our ability to manipulate NK cells in HSCT.

KW - Acute myeloid leukemia

KW - Allogeneic stem cell transplantation

KW - Graft versus host disease

KW - Graft versus leukemia

KW - Immunotherapy

KW - KIR

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DO - 10.1016/j.leukres.2010.07.030

M3 - Review Article

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SN - 0145-2126

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JO - Leukemia Research

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Alloreactive natural killer cells in hematopoietic stem cell transplantation

Abstract

Keywords

UN SDGs

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