Allogeneic mesenchymal stem cells injections for the treatment of bronchiolitis obliterans syndrome following allogeneic hematopoietic stem cells transplant

Xing-Wei Liang, Hailong Xia, Yongqing Wang, Robert Chunhua Zhao

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Bronchiolitis Obliterans Syndrome (BOS) is a well-recognized complication of allogeneic Hematopoietic Stem Cell Transplantation (HSCT). The management of bronchiolitis obliterans has been frustrating, with patients developing progressive Air Flow Obstruction (AFO). The purpose of this study was to evaluate the efficacy of human Bone Marrow Derived Mesenchymal Stem Cells (BMMSC) as the salvage therapy for BOS after HSCT. One patient with BOS received intravenous infusions of BMMSC at a dose of 1.5×10 6/kg per patients' weight, and rapid recovery from BOS without any side effects was observed. We concluded that BMMSC seems to be a promising therapeutic method in patients with BOS after HSCT.

Original languageEnglish
Pages (from-to)185-187
Number of pages3
JournalJournal of Cancer Science & Therapy
Volume4
Issue number7
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Bronchiolitis obliterans syndrome
  • Graft-versus-host-disease
  • Hematopoietic stem cells transplantation
  • Mesenchymal stem cells

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