Allelic variation in dopamine D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11)

Jasmine B. Taylor, Tarrant D R Cummins, Allison M. Fox, Beth P. Johnson, Janette H Tong, Troy A W Visser, Ziarih Hawi, Mark Bellgrove

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objectives: Previous studies have postulated that noradrenergic and/or dopaminergic gene variations are likely to underlie individual differences in impulsiveness, however, few have shown this. The current study examined the relationship between catecholamine gene variants and self-reported impulsivity, as measured by the Barratt Impulsiveness Scale (Version 11; BIS-11) Methods: Six hundred and seventy-seven non-clinical adults completed the Barratt Impulsiveness Scale (BIS-11). DNA was analysed for a set of 142 single-nucleotide polymorphisms (SNPs) across 20 autosomal catecholamine genes. Association was tested using an additive regression model with permutation testing used to control for the influence of multiple comparison. Results: Analysis revealed an influence of rs4245146 of the dopamine D2 receptor (DRD2) gene on the BIS-11 attention first-order factor, such that self-reported attentional impulsiveness increased in an additive fashion with each copy of the T allele. Conclusions: These findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses.

Original languageEnglish
Pages (from-to)S75-S83
Number of pages9
JournalWorld Journal of Biological Psychiatry
Volume19
Issue numberS2
DOIs
Publication statusPublished - 20 Jan 2017

Keywords

  • attention
  • BIS
  • catecholamine
  • DRD2
  • impulsivity

Cite this

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title = "Allelic variation in dopamine D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11)",
abstract = "Objectives: Previous studies have postulated that noradrenergic and/or dopaminergic gene variations are likely to underlie individual differences in impulsiveness, however, few have shown this. The current study examined the relationship between catecholamine gene variants and self-reported impulsivity, as measured by the Barratt Impulsiveness Scale (Version 11; BIS-11) Methods: Six hundred and seventy-seven non-clinical adults completed the Barratt Impulsiveness Scale (BIS-11). DNA was analysed for a set of 142 single-nucleotide polymorphisms (SNPs) across 20 autosomal catecholamine genes. Association was tested using an additive regression model with permutation testing used to control for the influence of multiple comparison. Results: Analysis revealed an influence of rs4245146 of the dopamine D2 receptor (DRD2) gene on the BIS-11 attention first-order factor, such that self-reported attentional impulsiveness increased in an additive fashion with each copy of the T allele. Conclusions: These findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses.",
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author = "Taylor, {Jasmine B.} and Cummins, {Tarrant D R} and Fox, {Allison M.} and Johnson, {Beth P.} and Tong, {Janette H} and Visser, {Troy A W} and Ziarih Hawi and Mark Bellgrove",
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Allelic variation in dopamine D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11). / Taylor, Jasmine B.; Cummins, Tarrant D R; Fox, Allison M.; Johnson, Beth P.; Tong, Janette H; Visser, Troy A W; Hawi, Ziarih; Bellgrove, Mark.

In: World Journal of Biological Psychiatry, Vol. 19, No. S2, 20.01.2017, p. S75-S83.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Taylor, Jasmine B.

AU - Cummins, Tarrant D R

AU - Fox, Allison M.

AU - Johnson, Beth P.

AU - Tong, Janette H

AU - Visser, Troy A W

AU - Hawi, Ziarih

AU - Bellgrove, Mark

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N2 - Objectives: Previous studies have postulated that noradrenergic and/or dopaminergic gene variations are likely to underlie individual differences in impulsiveness, however, few have shown this. The current study examined the relationship between catecholamine gene variants and self-reported impulsivity, as measured by the Barratt Impulsiveness Scale (Version 11; BIS-11) Methods: Six hundred and seventy-seven non-clinical adults completed the Barratt Impulsiveness Scale (BIS-11). DNA was analysed for a set of 142 single-nucleotide polymorphisms (SNPs) across 20 autosomal catecholamine genes. Association was tested using an additive regression model with permutation testing used to control for the influence of multiple comparison. Results: Analysis revealed an influence of rs4245146 of the dopamine D2 receptor (DRD2) gene on the BIS-11 attention first-order factor, such that self-reported attentional impulsiveness increased in an additive fashion with each copy of the T allele. Conclusions: These findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses.

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