All in the family: TGF-beta family action in testis development

Catherine Itman, Sirisha Heloise Shalini Mendis, Badia Maria Barakat, Katherine Ann Lakoski Loveland

Research output: Contribution to journalArticleResearchpeer-review

139 Citations (Scopus)

Abstract

To achieve and maintain fertility, the adult mammalian testis produces many generations of sperm. While testicular integrity is established in the fetus and develops further in juvenile life, sperm production does not ensue until much later in life, following the onset of puberty. Signals from the transforming growth factor-b superfamily of proteins are vital for governance of testis development and spermatogenesis, and this review discusses our current understanding of the mechanisms and processes in which they have been implicated with a focus on the fetal and juvenile testis
Original languageEnglish
Pages (from-to)233 - 246
Number of pages14
JournalReproduction
Volume132
Issue number2
DOIs
Publication statusPublished - 2006

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