Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity

Wan Nurul Nazneem Wan Othman, Yasodha Sivasothy, Sook Yee Liew, Jamaludin Mohamad, Mohd Azlan Nafiah, Kartini Ahmad, Marc Litaudon, Khalijah Awang

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

(−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-N-methyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine (6), crychine (7), (−)-isocaryachine (8), (+)-reticuline (9), (−)-desmethylsecoantofine (10), (+)-oridine (11), dicentrinone (12) and (−)-antofine (13) were also isolated with compounds 4, 7–9 and 12–13 being characterized for the first time in this plant. Compounds 1-3 were moderate to weak AChE and BChE inhibitors while compound 10 was a DPPH free radical scavenger.

Original languageEnglish
Pages (from-to)230-236
Number of pages7
JournalPhytochemistry Letters
Volume21
DOIs
Publication statusPublished - Sept 2017
Externally publishedYes

Keywords

  • (−)-Desmethylsecoantofine N-oxide
  • Cholinesterase inhibitory activities
  • Cryptocarya densiflora Blume
  • DPPH free radical scavenging activity
  • Prodensiflorin A
  • Prodensiflorin B

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