TY - JOUR
T1 - Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity
AU - Wan Othman, Wan Nurul Nazneem
AU - Sivasothy, Yasodha
AU - Liew, Sook Yee
AU - Mohamad, Jamaludin
AU - Nafiah, Mohd Azlan
AU - Ahmad, Kartini
AU - Litaudon, Marc
AU - Awang, Khalijah
N1 - Funding Information:
The authors acknowledge University of Malaya for providing the University Research Grants (PPP: PV049/2012A) and (UMRP: RP001-2012A/B) which has made this work possible. This work is within a collaborative program between CNRS and University of Malaya (LIA-IFM NatProLab). The authors would like to thank Mr. Teo Leong Eng, Mr. Din and Mr. Rafly Syamsir from the Herbarium group of the Department of Chemistry, University of Malaya, for assisting in the collection and identification of the plant material as well as in the preparation of its voucher specimen.
Publisher Copyright:
© 2017 Phytochemical Society of Europe
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/9
Y1 - 2017/9
N2 - (−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-N-methyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine (6), crychine (7), (−)-isocaryachine (8), (+)-reticuline (9), (−)-desmethylsecoantofine (10), (+)-oridine (11), dicentrinone (12) and (−)-antofine (13) were also isolated with compounds 4, 7–9 and 12–13 being characterized for the first time in this plant. Compounds 1-3 were moderate to weak AChE and BChE inhibitors while compound 10 was a DPPH free radical scavenger.
AB - (−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-N-methyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine (6), crychine (7), (−)-isocaryachine (8), (+)-reticuline (9), (−)-desmethylsecoantofine (10), (+)-oridine (11), dicentrinone (12) and (−)-antofine (13) were also isolated with compounds 4, 7–9 and 12–13 being characterized for the first time in this plant. Compounds 1-3 were moderate to weak AChE and BChE inhibitors while compound 10 was a DPPH free radical scavenger.
KW - (−)-Desmethylsecoantofine N-oxide
KW - Cholinesterase inhibitory activities
KW - Cryptocarya densiflora Blume
KW - DPPH free radical scavenging activity
KW - Prodensiflorin A
KW - Prodensiflorin B
UR - http://www.scopus.com/inward/record.url?scp=85024094395&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2017.07.002
DO - 10.1016/j.phytol.2017.07.002
M3 - Article
AN - SCOPUS:85024094395
VL - 21
SP - 230
EP - 236
JO - Phytochemistry Letters
JF - Phytochemistry Letters
SN - 1874-3900
ER -